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Dipeptidyl peptidase 4 Antibodies
AND DPP4 ELISA kits, Dipeptidyl peptidase 4 Proteins
Many biological assays use antibodies to detect Dipeptidyl peptidase 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dipeptidyl peptidase 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dipeptidyl peptidase 4 antibodies...
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DPP4 Infographic by Boster Bio
All DPP4 Products
Product
Figures
Specificity
Applications
Price
Human CD26/DPP4 ELISA Kit PicoKine®
7 Citations 10 Q&As
Human
ELISA
$499
Cat # EK0696
96 wells/kit, with removable strips.
Cat # EK0696
96 wells/kit, with removable strips.
Mouse CD26/DPP4 ELISA Kit PicoKine®
1 Citations 8 Q&As
Mouse
ELISA
$499
Cat # EK0697
96 wells/kit, with removable strips.
Cat # EK0697
96 wells/kit, with removable strips.
Anti-CD26/DPP4 Rabbit Monoclonal Antibody
1 Citations 3 Q&As
Human, Mouse, Rat
WB
$370
Cat # M00597
100 μl
Cat # M00597
100 μl
Mouse
Flow Cytometry, IP, IHC-F
$299
Cat # M00597-1
0.1 mg
Cat # M00597-1
0.1 mg
Enzyme Activity, SDS-PAGE
$265
Cat # PROTP27487
Starting from 20ug
Cat # PROTP27487
Starting from 20ug
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00597-2
100 µl
Cat # M00597-2
100 µl
Human CD26/DPP4 PicoKine® Quick ELISA Kit
1 Citations
Human
ELISA
$499
Cat # FEK0696
96 wells/kit, with removable strips.
Cat # FEK0696
96 wells/kit, with removable strips.
DPP4 Overview
Facts about Dipeptidyl peptidase 4.
Dipeptidyl peptidase 4 (DPP4)
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at ADA, CAV1, IGF2R, and PTPRC.
Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent method. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion.
Gene Information
| Human | |
|---|---|
| Gene Name: | DPP4 |
| Uniprot: | P27487 |
| Entrez: | 1803 |
Family
| Belongs to: |
|---|
| peptidase S9B family |
Alternative Names
ADABP; ADCP-2; ADCP2DPP IV; Adenosine deaminase complexing protein 2TP103; CD26 antigen; CD26; CD26T-cell activation antigen CD26; dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidyl-peptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP4; DPPIV; EC 3.4.14.5
Molecular Weight
Mass (kDA):
88.279 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.2 |
| Sequence: | 2; NC_000002.12 (161992241..162074215, complement) |
Tissue Specificity
Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
Subcellular Localizations
[Dipeptidyl peptidase 4 soluble form]: Secreted. Detected in the serum and the seminal fluid.; Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft. Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Hypoglycemia
- Malignant Neoplasms
- Obesity
- Neoplasms
- Insulin Resistance
- Hyperglycemia
- Inflammation
- Carcinoma
- Cardiovascular Diseases
- Malignant Paraganglionic Neoplasm
- Insulin Sensitivity
Interacting Proteins
- CCL11
- CXCL10
- CXCL11
- CXCL2
- CXCL9
- GCG
- VIP
Pathways
- Secretion
- Insulin Secretion
- Glucagon Secretion
- Glucose Homeostasis
- Fibroblast Activation
- Pathogenesis
- Gastric Emptying
- Transport
- Cell Activation
- Localization
- T Cell Activation
- Cell Proliferation
- Regeneration
PTMs
- Cleavage
- Glycosylation
- Phosphorylation
- Amidation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DPP4
bosterbio.com/bosterbio-gene-info-cards/DPP4
References
PMID: 1352704 by Misumi Y., et al. Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface.
PMID: 1347043 by Darmoul D., et al. Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.
10 Publications of Boster Dipeptidyl peptidase 4 Antibodies & ELISA Kits
- PubMed ID: 10.2217/fon-2018-0725, Diagnostic and prognostic significance of serum CD26 level in Asian women with h...
- PubMed ID: 10.1186/s12885-015-1757-0, Serum CD26 levels in patients with gastric cancer: a novel potential diagnostic ...
- PubMed ID: 10.1152/ajpendo.00323.2019, DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-ind...
- PubMed ID: 10.1080/1028602042000325609, Effects of isoliensinine on angiotensin II-induced proliferation of porcine coro...
- PubMed ID: 10.1016/j.arcmed.2016.07.005, Prognostic Significance of Serum CD26 Concentration in Patients with Esophageal ...
- PubMed ID: , CD26/DPP4 - a potential biomarker and target for cancer therapy
- PubMed ID: 29254987, DPP-4 inhibitors improve diabetic wound healing via direct and indirect promotio...
- PubMed ID: 26471376, Serum CD26 levels in patients with gastric cancer: a novel potential diagnostic ...
- PubMed ID: 26192450, Extra virgin olive oil use is associated with improved post-prandial blood gluco...
- PubMed ID: 3024064, KLF4 promotes hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia ce...
*More publications can be found for each product on its corresponding product page