Dock11 Antibodies

AND Dock11 ELISA kits, Dock11 Proteins

Many biological assays use antibodies to detect Dock11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dock11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dock11 antibodies...

We validate the specificity of these antibodies to Dock11 by testing them on tissues known to express Dock11 positively and negatively. Browse below to find the Dock11 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Dock11 Infographic by Boster Bio

All Dock11 Products

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Product

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Specificity

Applications

Price

Anti-DOCK11 Antibody

Human, Mouse, Rat

$405
Cat # A12259
100ul

DOCK11 (NM_144658) Human Over-expression Lysate

Human

$960
Cat # LS139818
100 µg

Dock11 Overview

Facts about Dedicator of cytokinesis protein 11.

Dedicator of cytokinesis protein 11 (Dock11)

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is related to early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399).

Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997). .

Gene Information

Mouse
Gene Name:	Dock11
Uniprot:	A2AF47
Entrez:	75974

Family

Belongs to:

DOCK family

Alternative Names

ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1; bB128O4.1.1 (novel protein); dedicator of cytokinesis 11; FLJ32122; FLJ43653; ZIZ2dedicator of cytokinesis protein 11; zizimin2; zizimin-2

Molecular Weight

Mass (kDA):
237.771 kDA

Genomic Context


Mouse

Location:	X\|X A3.3
Sequence:	X;

Tissue Specificity

Expressed in spleen, thymus, mesenteric lymph nodes (MLN), bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers. Expressed in B-, T- and dendritic cells as well as Purkinje cells (PubMed:22494997, PubMed:25851601).

Diseases

Neuroblastoma
Impacted Tooth
Testicular Neoplasms
Polyploidy
Hypoxia
Avascular Necrosis Of Bone
Neoplasms, Germ Cell And Embryonal
Carcinoma
Carcinoma In Situ
Retinoblastoma
Tumor Angiogenesis
Malignant Neoplasms

Neoplasms
Nervousness
Pituitary Diseases
Leukemia
Pituitary Neoplasms
Lymphoid Leukemia
Chronic Lymphocytic Leukemia

Pathways

Aging
Cytokinesis
Sensitization
Cell Migration
Cell Cycle
Establishment Of Cell Polarity
Immune Response
Cell Growth

Angiogenesis
Regulation Of Cell Growth

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dock11

References

PMID: 15710388 by Nishikimi A., et al. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.

PMID: 16968698 by Lin Q., et al. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.