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DNAJC3 Antibodies
AND DNAJC3 ELISA kits, DNAJC3 Proteins
Many biological assays use antibodies to detect DNAJC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNAJC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNAJC3 antibodies...
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DNAJC3 Overview
Facts about DnaJ homolog subfamily C member 3.
DnaJ homolog subfamily C member 3 (DNAJC3)
Involved in the unfolded protein response (UPR) through endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at'Ser-52' and hence attenuating overall protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity).
Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A.
Gene Information
| Human | |
|---|---|
| Gene Name: | DNAJC3 |
| Uniprot: | Q13217 |
| Entrez: | 5611 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DnaJ (Hsp40) homolog, subfamily C, member 3; HP58; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; P58FLJ21288; P58IPKProtein kinase inhibitor p58; PRKRIdnaJ homolog subfamily C member 3; Protein kinase inhibitor of 58 kDa; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
Molecular Weight
Mass (kDA):
57.58 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q32.1 |
| Sequence: | 13; NC_000013.11 (95677139..95794988) |
Tissue Specificity
Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Subcellular Localizations
Endoplasmic reticulum.
Diseases
- Influenza
- Virus Diseases
- Endoplasmic Reticulum Stress
- Diabetes Mellitus
- Physiological Stress
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Neoplasms
- Retinal Diseases
- Acute Leukemia
- Inflammation
- Hyperglycemia
Pathways
- Translation
- Protein Folding
- Cell Growth
- Cell Death
- Pathogenesis
- Secretion
- Transport
- Localization
- Viral Replication
- Programmed Cell Death
- Protein Maturation
- Aging
- Virulence
PTMs
- Phosphorylation
Research Areas
- Cellular Markers
- Golgi Apparatus Markers
- Lipid and Metabolism
- Unfolded Protein Response
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNAJC3
bosterbio.com/bosterbio-gene-info-cards/DNAJC3
References
PMID: 8666242 by Korth M.J., et al. Cloning, expression, and cellular localization of the oncogenic 58- kDa inhibitor of the RNA-activated human and mouse protein kinase.
PMID: 8576172 by Polyak S.J., et al. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.