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DMP1 Antibodies
AND DMP1 ELISA kits, DMP1 Proteins
Many biological assays use antibodies to detect DMP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DMP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DMP1 antibodies...
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DMP1 Infographic by Boster Bio
All DMP1 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK1290
96 wells/kit, with removable strips.
Cat # EK1290
96 wells/kit, with removable strips.
DMP1 Overview
Facts about Dentin matrix acidic phosphoprotein 1.
Dentin matrix acidic phosphoprotein 1 (DMP1)
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin.
During the osteoblast to osteocyte transition phase it is phosphorylated and exported to the extracellular matrix, where it regulates nucleation of hydroxyapatite. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DMP1 |
| Uniprot: | Q13316 |
| Entrez: | 1758 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ARHP; ARHR; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; Dentin matrix protein 1; DMP1; DMP-1
Molecular Weight
Mass (kDA):
55.782 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.1 |
| Sequence: | 4; NC_000004.12 (87650280..87664357) |
Tissue Specificity
Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
Subcellular Localizations
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Diseases
- Rickets
- Hypophosphatemic Rickets
- Familial Hypophosphatemic Bone Disease
- Hypophosphatemia
- Neoplasms
- Malignant Neoplasms
- Osteomalacia
- Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
- Dentinogenesis Imperfecta
- Hypertrophy
- Kidney Diseases
- Cell Transformation, Neoplastic
Pathways
- Dentinogenesis
- Odontoblast Differentiation
- Regeneration
- Osteoblast Differentiation
- Bone Mineralization
- Dentin Mineralization
- Localization
- Cell Proliferation
- Secretion
- Cell Differentiation
- Ossification
- Cell Cycle
- Bone Remodeling
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DMP1
bosterbio.com/bosterbio-gene-info-cards/DMP1
References
PMID: 9177774 by Hirst K.L., et al. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.
PMID: 8586437 by Aplin H.M., et al. Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21.