Diaph3 Antibodies

AND Diaph3 ELISA kits, Diaph3 Proteins

Many biological assays use antibodies to detect Diaph3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Diaph3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Diaph3 antibodies...

We validate the specificity of these antibodies to Diaph3 by testing them on tissues known to express Diaph3 positively and negatively. Browse below to find the Diaph3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Diaph3 Infographic by Boster Bio

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DIAPH3 (NM_001042517) Human Over-expression Lysate

Human

$960
Cat # LS081624
100 µg

Diaph3 Overview

Facts about Protein diaphanous homolog 3.

Protein diaphanous homolog 3 (Diaph3)

Binds to GTP-bound form of Rho and to profilin.
Acts in a Rho-dependent way to recruit profilin to the membrane, where it promotes actin polymerization.

It's required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response element. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics.

Gene Information

Mouse
Gene Name:	Diaph3
Uniprot:	Q9Z207
Entrez:	56419

Family

Belongs to:

formin homology family

Alternative Names

DIAP3; diaphanous homolog 3 (Drosophila); diaphanous-related formin 3; DKFZp434C0931; DKFZp686A13178; homolog) 3; mDia2; protein diaphanous homolog 3

Molecular Weight

Mass (kDA):
133.686 kDA

Genomic Context


Mouse

Location:	14\|14 E1
Sequence:	14;

Diseases

Malignant Neoplasms
Neoplasms
Auditory Neuropathy
Neoplasm Metastasis
Chondrosarcoma
Malignant Neoplasm Of Pancreas
Bulla
Cell Invasion
Complete Hearing Loss
Tissue Adhesions
Autistic Disorder
Autoimmunity

Parathyroid Neoplasms
Carcinogenesis
Carcinoma
Carcinoid Tumor
Status Epilepticus
Epilepsy, Rolandic
Meningioma

Pathways

Localization
Cell Adhesion
Cell Migration
Brain Development
Mitosis
Cytokinesis
Cell Division
Cell Motility
Actin Nucleation
Proteolysis
Glycosylation
Metaphase
Chromosome Segregation

Limb Morphogenesis
Axon Guidance
Locomotion
Pathogenesis
Rna Interference
Tissue Homeostasis
Secretion

PTMs

Phosphorylation

Glycosylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Diaph3

References

PMID: 9535835 by Alberts A.S., et al. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.

PMID: 10678165 by Tominaga T., et al. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.