DHRS4 Antibodies

AND DHRS4 ELISA kits, DHRS4 Proteins

Many biological assays use antibodies to detect DHRS4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DHRS4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DHRS4 antibodies...

We validate the specificity of these antibodies to DHRS4 by testing them on tissues known to express DHRS4 positively and negatively. Browse below to find the DHRS4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DHRS4 Infographic by Boster Bio

All DHRS4 Products

Product

Figures

Specificity

Applications

Price

Anti-DHRS4 Antibody

4 Q&As

Human

IHC, WB

$360
Cat # A07990
100 µl

Anti-DHRS4 Antibody

Human, Mouse, Rat

$405
Cat # A07990-1
100ul

Human DHRS4 Recombinant Protein

SDS-PAGE

$350
Cat # PROTQ9BTZ2
Starting from 10ug

DHRS4 (NM_021004) Human Over-expression Lysate

Human

$628
Cat # LS010901
100 µg

DHRS4 Overview

Facts about Dehydrogenase/reductase SDR family member 4.

DHRS4 3D structure. Source: alphafold

Dehydrogenase/reductase SDR family member 4 (DHRS4)

Reduce all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- variable, but with much lower efficiency.

Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Gene Information

Human
Gene Name:	DHRS4
Uniprot:	Q9BTZ2
Entrez:	10901

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

CR; dehydrogenase/reductase (SDR family) member 4 like 2A; dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase SDR family member 4; EC 1.1.1; EC 1.1.1.184; FLJ11008; humNRDR; NADP-dependent retinol dehydrogenase; NRDRNADPH-dependent retinol dehydrogenase/reductase; Peroxisomal short-chain alcohol dehydrogenase; PHCR; PSCD; SCAD-SRLNADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; SDR25C1; SDR25C2; SDR-SRL; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; Short-chain dehydrogenase/reductase family

Molecular Weight

Mass (kDA):
29.537 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (23953735..23969279)

Tissue Specificity

Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Subcellular Localizations

Peroxisome. Isoform 1 is peroxisomal, while isoform 4 is not.; [Isoform 7]: Nucleus.

Diseases

Neuroblastoma
Malignant Neoplasms
Corneal Diseases
Liver Carcinoma
Conjunctival Diseases
Liver Neoplasms
Refractory Anemia With Ringed Sideroblasts
Esophageal Neoplasms

Malignant Tumor Of Cervix
Carcinoma

Pathways

Methylation
Localization
Translation
Dna Methylation
Demethylation

PTMs

Methylation
Demethylation

Reduction
Deacetylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DHRS4

References

PMID: 10333503 by Fransen M., et al. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase.

PMID: 15473316 by Du J., et al. cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics.