DDX11 Antibodies

AND DDX11 ELISA kits, DDX11 Proteins

Many biological assays use antibodies to detect DDX11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDX11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDX11 antibodies...

We validate the specificity of these antibodies to DDX11 by testing them on tissues known to express DDX11 positively and negatively. Browse below to find the DDX11 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DDX11 Infographic by Boster Bio

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Anti-DDX11 Antibody

Human

$405
Cat # A05554
100ul

DDX11 Overview

Facts about ATP-dependent DNA helicase DDX11.

DDX11 3D structure. Source: alphafold

ATP-dependent DNA helicase DDX11 (DDX11)

DNA-dependent ATPase and ATP-dependent DNA helicase that participates in a variety of roles in genomic stability, including DNA replication, DNA repair and heterochromatin organization in addition to in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single- stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414).

The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp from the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase actions on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three- stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245).

Gene Information

Human
Gene Name:	DDX11
Uniprot:	Q96FC9
Entrez:	1663

Family

Belongs to:

DEAD box helicase family

Alternative Names

CHL1CHL1-related helicase gene-1; CHL1-related protein 1; CHLR1MGC9335; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S.cerevisiae); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (S.cerevisiae CHL1-likehelicase); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H box protein 11; EC 3.6.1; EC 3.6.1.23; EC 3.6.1.7; EC 3.6.4.13; hCHLR1; Keratinocyte growth factor-regulated gene 2 protein; KRG-2; KRG2CHL1-like helicase homolog; MGC133249; probable ATP-dependent RNA helicase DDX11

Molecular Weight

Mass (kDA):
108.313 kDA

Genomic Context


Human

Location:	12p11.21
Sequence:	12; NC_000012.12 (31073860..31104799)

Tissue Specificity

Expressed in melanoma cells. Not detected in epidermal melanocytes of normal skin (at protein level) (PubMed:23116066). Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine and pancreas (PubMed:9013641). Very low expression seen in brain (PubMed:9013641). Expressed in dividing cells and/or cells undergoing high levels of recombination (PubMed:9013641). No expression detected in cells signaled to terminally differentiate (PubMed:9013641). Expressed weakly in keratinocytes (PubMed:8798685).

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase) (PubMed:17105772). In interphase, colocalizes with nucleolin in the nucleolus (PubMed:26089203).; Chromosome. (Microbial infection) Colocalizes with bovine papillomavirus type 1 regulatory prote

Diseases

Fanconi Anemia
Anemia
Malignant Neoplasms
Neoplasms
Chromosome Breakage
Hereditary Diseases
Xeroderma
Xeroderma Pigmentosum
Coronary Heart Disease
Epithelioma
Melanoma
Malignant Neoplasm Of Breast
Swine Diseases

Werner Syndrome
Head And Neck Carcinoma
Cornelia De Lange Syndrome
Premature Aging Syndrome
Invasive Skin Melanoma
Aneuploidy
Carcinoma

Pathways

Sister Chromatid Cohesion
Localization
Dna Repair
Chromosome Segregation
Cell Cycle
Cell Proliferation
Heterochromatin Organization
Aging
Dna Methylation
Hypersensitivity
Pigmentation
Metaphase
Establishment Of Sister Chromatid Cohesion

Cell Cycle Arrest
Senescence
Methylation
Reverse Transcription
Diakinesis
Translation
Cell Death

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDX11

References

PMID: 8798685 by Frank S., et al. The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor regulated gene.

PMID: 9013641 by Amann J., et al. Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.