Dysferlin Antibodies

Dysferlin (DYSF)

Key calcium ion detector included in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).

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Gene Information

Human
Gene Name:	DYSF
Uniprot:	O75923
Entrez:	8291

Family

Belongs to:
ferlin family

Alternative Names

dysferlin; dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive); dystrophy-associated fer-1-like 1; FER1L1Dystrophy-associated fer-1-like protein; Fer-1-like protein 1; FLJ00175; FLJ90168; LGMD2B

Molecular Weight

Mass (kDA):
237.295 kDA

Genomic Context

Human
Location:	2p13.2
Sequence:	2; NC_000002.12 (71453154..71686763)

Tissue Specificity

Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas.

Subcellular Localizations

Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Cell membrane. Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca(2+)-dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncy

Diseases

• Muscular Dystrophy
• Dystrophy
• Muscular Dystrophies, Limb-girdle
• Myopathy
• Miyoshi Myopathy
• Distal Muscular Dystrophies
• Weakness
• Inflammation
• Muscle Weakness
• Myositis
• Atrophy
• Muscular Atrophy

• Sarcoglycanopathies
• Cardiomyopathies
• Neuromuscular Diseases
• Polymyositis
• Muscular Dystrophy, Animal
• Leyden-moebius Muscular Dystrophy

Interacting Proteins

• ACTN2
• ALMS1
• APPL1
• CMYA5
• DES

• DGKD
• DNAJB6
• FLNC
• MYBPC1
• MYOM1

• MYOM2
• NEB
• OPTN
• SAMHD1
• SGCG

• SNAPIN
• TTN

Pathways

• Localization
• Pathogenesis
• Regeneration
• Membrane Fusion
• Muscle Atrophy
• Translation
• Vesicle Fusion
• Inflammatory Response
• Phagocytosis
• Exocytosis
• Myoblast Fusion
• Plasma Membrane Repair
• Endocytosis

• Transport
• Cell Activation
• Cell Adhesion
• Spermatogenesis
• Lipid Binding
• Autophagy
• Response To Lipopolysaccharide

PTMs

• Phosphorylation
• Cleavage
• Reduction
• Deacetylation

• Biotinylation
• Acetylation
• Oxidation
• Methylation

• Dephosphorylation

Research Areas

• Cell Biology
• Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYSF

Boster Bio - Best Uses Of The DYSF Marker

Nerve growth hormone (NGF), which regulates the development targeted neurons in central and peripheral nerve systems, is called Nerve Growth Factor. This molecule shares a lot of homology with many species and is involved at multiple biological activities. It is also vital in the immune function, as it ensures survival and proliferation in beta cells of the pancreas. Boster Bio's DYSF peptide reflects that complex biology.

ACE2 Marker

Boster Bio's ACE2 marker is a small molecule that binds a portion of human ACE2 (1 to 230 amino acids). Although there are other peptides available that block binding at the same epitope as ACE2, ACE2 is the best. The manufacturer sells this product directly. Prices can vary depending on the size and length of the immunogen.

This protein is found within ciliated and goblet cell cultures in air-liquid interface culture and epithelial regenerators. It was found that differentiating cells acquire ACE2 more readily than non-differentiating ones, which could be important in understanding SARS-CoV-2 pathogenesis. This study is one of many that support the notion of a gene based signature in tumorigenesis.

The human blood level of ACE2 varies between sexes. Therefore, levels of ACE2 might be higher in males than in females. Mice lacking ACE2 have experienced tissue injury due to ACE2. Additionally, the SARS-CoV-2 virus requires ACE2 to infect cells. However, this relationship is not clear. ACE2 is a promising marker to assess COVID-19 risk.

ACE2 is also known to prime the HR1 protein for enhanced fusion. This receptor is necessary for SARS-CoV-2 transmission and infection. It also primes the HR1 receptor for enhanced fusion, cellular entry, and fusion. It is thought that inhibition of SARS-CoV-2 through ACE2 may result in new inhibitory therapeutics. This is why the ACE2 Marker in Boster Bio is the first of its kind.

Boster Bio's ACE2 marker indicates that a candidate gene is available for the ACE2 Protein. It is found in all body tissues. The ACE2 PCR product contains a 369-bp segment. Different genotypes showed different cleavage patterns. The GA genotype produced three fragments with 369 bp. Two fragments were produced by the AA and GG genotypes, respectively. Goodness of fit test confirmed this equilibrium. Additionally, it was associated a representative sample.

Although the association between ACE2 expression, adipose tissues severity and COVID-19 is not known, it is believed to be. These findings require further studies to identify whether COVID-19 severity is due to decreased expression of ACE2.

ACE2 may be a regulator and antagonist of Ang II. Genetic evidence suggests ACE2 plays a central component in the disease. ACE2 is a candidate for therapeutic intervention for a number of cardiovascular diseases. Its role in regulating blood pressure has been a long-time focus for scientists. It is a promising indicator that many other diseases will soon be possible.

NGF Marker

Nerve Growth Factor is a peptide hormone that regulates sensory neuron differentiation and growth. It is believed that it is one of the key mediators for allergic rhinitis. It is expressed by inflammatory cells and could play an important part in allergic rhinitis. Boster Bio stocks a variety antibodies against NGF. They include a Mouse NGF antibody and Human antibodies to NGF.

The NGF marker for human cells has many uses, but is most commonly used to promote cellular differentiation. It is a dimer consisting of two polypeptide chains and 120 amino acids. Scientists can submit their results to receive product credit and special samples. Researchers in any country may use the boster Bio. Boster Bio's NGF antibody is also available for research purposes.