Dymeclin Antibodies

AND DYM ELISA kits, Dymeclin Proteins

Many biological assays use antibodies to detect Dymeclin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dymeclin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dymeclin antibodies...

We validate the specificity of these antibodies to Dymeclin by testing them on tissues known to express DYM positively and negatively. Browse below to find the DYM antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DYM Infographic by Boster Bio

All DYM Products

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Dymeclin (DYM) (NM_017653) Human Recombinant Protein

$1062
Cat # PROTQ7RTS9
20 µg

Dymeclin (DYM) (NM_017653) Human Over-expression Lysate

Human

$628
Cat # LS054808
100 µg

DYM Overview

Facts about Dymeclin.

DYM 3D structure. Source: alphafold

Dymeclin (DYM)

Necessary for correct organization of Golgi apparatus. Involved in bone development.

Gene Information

Human
Gene Name:	DYM
Uniprot:	Q7RTS9
Entrez:	54808

Family

Belongs to:

dymeclin family

Alternative Names

DMCSMCFLJ20071; Dyggve-Melchior-Clausen syndrome protein; dymeclin; FLJ90130

Molecular Weight

Mass (kDA):
75.935 kDA

Genomic Context


Human

Location:	18q21.1
Sequence:	18; NC_000018.10 (49036387..49460709, complement)

Tissue Specificity

Expressed in most embryo-fetal and adult tissues. Abundant in primary chondrocytes, osteoblasts, cerebellum, kidney, lung, stomach, heart, pancreas and fetal brain. Very low or no expression in the spleen, thymus, esophagus, bladder and thyroid gland.

Subcellular Localizations

Cytoplasm. Golgi apparatus. Membrane; Lipid-anchor. Sequence analysis programs clearly predict 1 transmembrane region. However, PubMed:18996921 shows that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol.

Diseases

Dysplasia
Dyggve-melchior-clausen Syndrome
Dwarfism
Osteochondrodysplasias
Microcephaly
Mucopolysaccharidosis Iv
Mucopolysaccharidoses
Bone Diseases, Developmental
Genetic Diseases, X-linked
Skeletal Dysplasia
Congenital Anomaly Of Face

Shortened Trunk
Leukemia
Growth Disorders
Chondrodysplasia Punctata
Pfaundler-hurler Syndrome

Pathways

Transport
Cell Death
Golgi Organization
Pathogenesis
Golgi Reassembly
Bone Development
Interphase
Protein Secretion

Localization
Secretion

PTMs

Cleavage

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYM

References

PMID: 12554689 by El Ghouzzi V., et al. Mutations in a novel gene dymeclin (FLJ20071) are responsible for Dyggve-Melchior-Clausen syndrome.

PMID: 18996921 by Dimitrov A., et al. The gene responsible for Dyggve-Melchior-Clausen syndrome encodes a novel peripheral membrane protein dynamically associated with the Golgi apparatus.