DUSP6 Antibodies

Dual specificity protein phosphatase 6 (DUSP6)

Inactivates MAP kinases.

Has a specificity for the ERK family (PubMed:9858808).

Plays an essential role in relieving chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).

Gene Information

Human
Gene Name:	DUSP6
Uniprot:	Q16828
Entrez:	1848

Family

Belongs to:
protein-tyrosine phosphatase family

Alternative Names

dual specificity phosphatase 6; Dual specificity protein phosphatase PYST1; DUSP6; EC 3.1.3.16; EC 3.1.3.48; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP3; MKP-3; MKP3serine/threonine specific protein phosphatase; PYST1; PYST1dual specificity protein phosphatase 6

Molecular Weight

Mass (kDA):
42.32 kDA

Genomic Context

Human
Location:	12q21.33
Sequence:	12; NC_000012.12 (89347235..89352501, complement)

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Pancreatic Neoplasm
• Malignant Neoplasm Of Pancreas
• Carcinogenesis
• Lung Neoplasms
• Malignant Neoplasm Of Lung
• Tissue Adhesions
• Neoplasm Invasiveness
• Adenocarcinoma
• Inflammation

• Malignant Squamous Cell Neoplasm
• Neoplasm Metastasis
• Cell Transformation, Neoplastic
• Non-small Cell Lung Carcinoma
• Skin Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms

Pathways

• Cell Proliferation
• Cell Cycle
• Pathogenesis
• Cell Growth
• Localization
• Cell Differentiation
• Cell Adhesion
• Regeneration
• Angiogenesis
• Cell Cycle Arrest
• Cell Death
• Cell Migration
• Nuclear Export

• Immune Response
• Epithelial Cell Proliferation
• Methylation
• Gluconeogenesis
• Histone Acetylation
• Dna Methylation
• Dna Repair

PTMs

• Phosphorylation
• Dephosphorylation
• Methylation
• Demethylation
• Cleavage

• Acetylation
• Oxidation
• Nitrosylation
• Reduction
• Glycosylation

• Deacetylation

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUSP6

Best Uses of the DUSP6 Marker in Cancer Research

DUSP6 is an MAPK Kinase that regulates ERK signaling and is involved in the growth of tumors. It may have tumor-promoting and suppressive properties in various conditions. This article will look at the many ways DUSP6 is used and its advantages and drawbacks in a range of different contexts. In addition, we'll look at some of the more interesting applications of DUSP6 in cancer research.

DUSP6 is an indicator of tumor-promoting

This study shows that the ovarian cancer cells suffer by the inhibition of the DUSP6 protein gene. Gene expression levels were measured using an Human Cancer Drug Resistance pathway targeted qPCR array within SKOV3 cells that were treated with carboplatin or BCI. The results suggest that DUSP6 expression reduces the rate of cell death caused by chemotherapy. However, the findings do not support the clinical utility of DUSP6 inhibition.

To determine if DUSP6 is involved in neuronal pathologies, researchers utilized the DUSP6 phosphatase enzyme to inhibit the dynamin-dependent internalization of the dopamine transporter. This inhibition was not as mirrored by the pharmacological inhibition of MAPKs. Furthermore, oxidative stress neurons could be linked with DUSP6-catalytic inhibition. This could play a role for Parkinson's and Alzheimer's diseases.

The DUSP6 gene is involved in the development of many human cancer cells. One study revealed that DUSP6 and HE4 were detected together in an ovarian carcinoma cell line. The results showed that DUSP6 was associated with tumorigenesis in ovarian carcinoma cells. These results, while still under investigation suggest a novel therapy option for ovarian carcinoma.

The expression of DUSP6 was associated with advanced stage and grade 2/3 tumors. Additionally, high levels of DUSP6 protein expression correlated with distant lymph node involvement and metastasis. Moreover, DUSP6 expression was associated with tumor-promoting activity and suggests that it is a function of this protein to predict cellular growth. However, it is important to note that this gene is only expressed in certain cancers.

It is a tumor-suppressive indicator

The phosphoproteomic analysis of human cancer cells suggests that DUSP6 could be a useful biomarker for the disease. The inactivation of DUSP6 induced the activation of the ATM-CHEK2 pathway , and increased the expression of markers for DNA breaks, suggesting that DUSP6 may be a tumor-suppressive marker. Furthermore, DUSP6 might play a role in regulating the reaction of cancer cells to targeted agents and DNA cytotoxic agents.

DUSP6 negatively regulates ERKs which is a signaling pathway involved in the growth and grcancrs. Ih wabeents shein to play a siifnditana role in the development oe ovarian cancon. Thifuessios proteiThis nnetected with ths ERg pathw,Ks which wabeents ippliclved in the development oe ovarian canconf DUSP6 waslsohe dcreovcted ay by expressed i3 tumong thastemos ie mivelf-prof human cancsll knce incrlyti fomacoretealts.

DUSPh wabeents shein ty be associated witl Horgh levels otwove i an MAPa signaling pathwaksaels tilaeld ita tumor-suppressive propertion. This suggests that DUSP6 could be keelfreaoher iESCCis. Mos, researiThirequivcted as nfirmby theosidativorrelatiohipld tweentt DUSP6 anald ttncerhstancs oeasvctills. These resulot support tho nssios that DUSPt is a tumor-suppressivm Marker iESCCis.