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DUSP6 Antibodies
AND DUSP6 ELISA kits, DUSP6 Proteins
Many biological assays use antibodies to detect DUSP6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DUSP6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DUSP6 antibodies...
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DUSP6 Infographic by Boster Bio
All DUSP6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02157
100 μl
Cat # M02157
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02157-2
100 μg/vial
Cat # A02157-2
100 μg/vial
DUSP6 Overview
Facts about Dual specificity protein phosphatase 6.
Dual specificity protein phosphatase 6 (DUSP6)
Inactivates MAP kinases.
Has a specificity for the ERK family (PubMed:9858808).Plays an essential role in relieving chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | DUSP6 |
| Uniprot: | Q16828 |
| Entrez: | 1848 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
dual specificity phosphatase 6; Dual specificity protein phosphatase PYST1; DUSP6; EC 3.1.3.16; EC 3.1.3.48; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP3; MKP-3; MKP3serine/threonine specific protein phosphatase; PYST1; PYST1dual specificity protein phosphatase 6
Molecular Weight
Mass (kDA):
42.32 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.33 |
| Sequence: | 12; NC_000012.12 (89347235..89352501, complement) |
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Pancreatic Neoplasm
- Malignant Neoplasm Of Pancreas
- Carcinogenesis
- Lung Neoplasms
- Malignant Neoplasm Of Lung
- Tissue Adhesions
- Neoplasm Invasiveness
- Adenocarcinoma
- Inflammation
Pathways
- Cell Proliferation
- Cell Cycle
- Pathogenesis
- Cell Growth
- Localization
- Cell Differentiation
- Cell Adhesion
- Regeneration
- Angiogenesis
- Cell Cycle Arrest
- Cell Death
- Cell Migration
- Nuclear Export
PTMs
- Phosphorylation
- Dephosphorylation
- Methylation
- Demethylation
- Cleavage
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUSP6
bosterbio.com/bosterbio-gene-info-cards/DUSP6
References
PMID: 8670865 by Groom L.A., et al. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.
PMID: 9858808 by Furukawa T., et al. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.