DUSP1 Antibodies

Dual specificity protein phosphatase 1 (DUSP1)

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Gene Information

Human
Gene Name:	DUSP1
Uniprot:	P28562
Entrez:	1843

Family

Belongs to:
protein-tyrosine phosphatase family

Alternative Names

CL100; CL100MAP kinase phosphatase 1; dual specificity phosphatase 1; Dual specificity protein phosphatase hVH1; DUSP1; EC 3.1.3.16; EC 3.1.3.48; HVH1; Mitogen-activated protein kinase phosphatase 1; MKP1; MKP-1; MKP-1dual specificity protein phosphatase 1; Protein-tyrosine phosphatase CL100; PTPN10; PTPN10serine/threonine specific protein phosphatase; VH1

Molecular Weight

Mass (kDA):
39.298 kDA

Genomic Context

Human
Location:	5q35.1
Sequence:	5; NC_000005.10 (172768096..172771195, complement)

Tissue Specificity

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Inflammation
• Carcinoma
• Inflammatory Response
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Liver Carcinoma
• Hypertrophy
• Hypoxia
• Malignant Paraganglionic Neoplasm
• Innate Immune Response
• Malignant Neoplasm Of Lung

• Lung Neoplasms
• Hypertensive Disease
• Cell Transformation, Neoplastic
• Atherosclerosis
• Neoplasm Metastasis
• Carcinogenesis
• Ovarian Neoplasm

Interacting Proteins

• MAPK1
• MAPK14
• MAPK3
• SKP2
• UBB

Pathways

• Cell Proliferation
• Cell Death
• Cell Growth
• Cell Cycle
• Inflammatory Response
• Pathogenesis
• Cytokine Production
• Immune Response
• Translation
• Secretion
• Localization
• Angiogenesis
• Rna Interference

• Cell Cycle Arrest
• Induction Of Apoptosis
• Regeneration
• Mapk Cascade
• Aging
• Response To Heat
• Cell Activation

PTMs

• Phosphorylation
• Dephosphorylation
• Cleavage
• Acetylation
• Ubiquitination
• Oxidation

• Biotinylation
• Methylation
• Nitrosylation
• Demethylation
• Nitration
• Reduction

• Deacetylation

Research Areas

• Cell Cycle and Replication
• Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUSP1

Boster Bio - Best Uses Of The DUSP1 Marker

You've probably heard about Boster Bio DUSP1 Marker However, have you used it? If not, this article is for you! This article will inform you about Boster Bio's past and its DUSP1 Marker ELISA platform. Learn about the antibody and ELISA platform, as well as the company's products and services.

Anti-DUSP1 antibody was purchased from Abcam

Abcam was in a position to supply me with the most appropriate and specific anti-DUSP1 antibody for my research. After further investigation I realized that Abcam was one of the most reliable suppliers of antibodies to this particular protein. The company provides a variety of antibodies that include rabbit anti-DUSP1 as well as 1:5000 antibody. The company also provides knockout and recombinant monoclonal cell lines. Its products support validation of experiments using gold-standard standards.

In this study, we examined the role played by DUSP1 in the development of OS. We employed RNA-Seq to determine Siglec-15 which enhances DUSP1 expression in OS cells. We constructed an inverse heat map and volcano plot and identified the top 10 genes affected by Siglec-15. Then, we analyzed them with RT-PCR. We also performed a Western Blotting assay to analyze cell invasion and migration.

DUSP1 acts as an anti-tumor agent and negatively regulates the function of MAPKs in human tumors. It also has an inherent regulatory mechanism that regulates cell proliferation and growth. Therefore, DUSP1 is a useful tool in treating SCCP. The company is confident that its products will improve the outlook for patients. We recommend you purchase this antibody from Abcam to conduct further studies.

This antibody was able recognize DUSP1 expression in lung epithelial cell. Using this antibody resulted in a decrease in lung LPS-induced injury. The compound was also discovered to enhance the activation of the JNK pathway, which inhibits the anti-inflammatory effect of the hypaphorine. The antibody can be purchased online from multiple sources. The manufacturer can be purchased directly.

Santa Cruz Biotechnology purchased the Anti-DUSP1 antibody

Western blotting shows that DUSP1 coexpresses with LINC01111. DUSP1 is part of the threonine/tyrosine family of dual specificity phosphatases. It dephosphorylates MAP Kinases such as ERKs and p38 MAPKs. DUSP1 plays a dual role at various stages of cancer development. In the beginning stages of cancer's development, the downregulation of DUSP1 encourages cell proliferation.

DUSP1 is located in the nucleus in the cytoplasm, as well as on the cell membrane. DUSP1 can block VEGF-induced proliferation and migration when it is overexpressed. It was previously observed that DUSP1 inhibits the activity of the ERK1/2 gene. Santa Cruz Biotechnology sells this antibody as a reagent for your research. You can purchase the antibody from many online retailers.

Cell Signaling, Santa Cruz Biotechnology and Dianova are only a few companies that sell anti DUSP1 antibodies. We also tested p38 monoclonal antibodies and p38 inhibitors SB203580. We employed a luciferase activation test to assess their effects on DUSP1. MiR-3924, miR-1290, and miR-4795-3p all decreased luciferase activity in the presence of wild-type DUSP1.

The Anti-DUSP1 antigen was purchased from Santa Cruz Biotechnology. LINC01111 blocks DUSP1 expression and alters DUSP1. The drug also modulates JNK/SAPK pathways. The study indicated that LINC01111 blocks DUSP1 expression by inhibiting PI3K. If DUSP1 inhibits PI3K/AKT, DUSP1 production will increase.

Boster Bio DUSP1 Marker ELISA platform

Boster Bio offers a unique platform for detecting DUSP1 protein in its native state. Scientists can submit their findings for species or applications using Boster Bio, and can also earn product credits. The DUSP1 marker is a very specific protein that is employed in a number of applications like drug discovery. For more information, contact Boster Bio today. Click here to purchase an ELISA for a DUSP1 marker.

The Picokine(tm) high-sensitivity ELISA platform allows researchers to increase ELISA levels to a picogram level. The Picokine(tm) ELISA platform is validated for use in a range of samples. Images as well as the validation process are available on request. The Picoband platform is based on the research and development of immunogens and technical assistance from BeNeLux distributor Sanbio.

IHC staining of DUSP1 Marker

In this study, we utilized immunohistochemistry (IHC) staining to examine the expression of the DUSP1 marker in cancer cells. We tested 101 gastric cancer tumors from patients who had recently diagnosed GC. One hundred nine patients were male with thirty females and all had given written informed consent before the study. We used a PannoramicMIDI tissue chip scanner developed by 3DHistech, Ltd.

To perform the experiments, we used MKN45 AR cells. AR cells showed significantly higher levels of DUSP1 than the cells of the parent. We also observed higher levels of p ERK in AR cells in comparison to parental cells. We also observed that higher Apa concentrations significantly increased p–ERK expression in MKN45 AR cells. Similar results were observed with Apa 5 uM. It significantly increased the p-ERK levels.

DUSP1 is a major macrophage-specific negative regulator and also the inflammation response to TLR signals. It plays a crucial role in both innate and adaptive immune responses. It is an essential negative-feedback regulator of p65/NFKB and also inactivates JNK and the MAPK p38. The gene has been implicated in a variety of human diseases, including severe PC and PIN lesions.

DUSP1 expression in DU145 cells reduces p38 MAPK, and DUSP1-mediated apoptosis. To confirm this cells that were DUSP1 transfected were incubated with TNF-a over a period of 48 hours. Cells were counted at the indicated times. These tests were repeated three times simultaneously. The results were the same in all cases.