Dual oxidase 1 Antibodies

AND DUOX1 ELISA kits, Dual oxidase 1 Proteins

Many biological assays use antibodies to detect Dual oxidase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dual oxidase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dual oxidase 1 antibodies...

We validate the specificity of these antibodies to Dual oxidase 1 by testing them on tissues known to express DUOX1 positively and negatively. Browse below to find the DUOX1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DUOX1 Infographic by Boster Bio

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DUOX1 (NM_017434) Human Over-expression Lysate

Human

$960
Cat # LS053905
100 µg

DUOX1 Overview

Facts about Dual oxidase 1.

DUOX1 3D structure. Source: alphafold

Dual oxidase 1 (DUOX1)

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa.

May have its own peroxidase activity through its N-terminal peroxidase-like domain. .

Gene Information

Human
Gene Name:	DUOX1
Uniprot:	Q9NRD9
Entrez:	53905

Family

Belongs to:

No superfamily

Alternative Names

dual oxidase 1; DUOX; EC 1.11.1.-; EC 1.6.3.1; Large NOX 1; LNOX1flavoprotein NADPH oxidase; Long NOX 1; MGC138840; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1MGC138841; Thyroid oxidase 1

Molecular Weight

Mass (kDA):
177.235 kDA

Genomic Context


Human

Location:	15q21.1
Sequence:	15; NC_000015.10 (45129994..45165578)

Tissue Specificity

Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Localizes to the apical membrane of epithelial cells.

Diseases

Hypothyroidism
Malignant Neoplasms
Carcinoma
Congenital Hypothyroidism
Inflammation
Neoplasms
Thyroid Neoplasm
Thyroid Diseases
Carcinoma, Papillary
Lung Diseases
Goiter
Thyroiditis
Malignant Paraganglionic Neoplasm

Malignant Neoplasm Of Thyroid
Adenoma
Hashimoto Disease
Cystic Fibrosis
Inflammatory Response
Chronic Obstructive Airway Disease
Fibrosis

Pathways

Localization
Secretion
Pathogenesis
Fertilization
Respiratory Burst
Transport
Immune Response
Virulence
Inflammatory Response
Phagocytosis
Cell Proliferation
Rna Interference
Cell Migration

Proteolysis
Respiratory Burst At Fertilization
Cell Death
Iodide Transport
Cell Adhesion
Aerobic Respiration
Response To Virus

PTMs

Phosphorylation
Iodination
Glycosylation
Cleavage

Oxidation
Reduction
Methylation
Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUOX1

References

PMID: 10806195 by De Deken X., et al. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.

PMID: 11514595 by Edens W.A., et al. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.