DTX4 Antibodies

AND DTX4 ELISA kits, DTX4 Proteins

Many biological assays use antibodies to detect DTX4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DTX4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DTX4 antibodies...

We validate the specificity of these antibodies to DTX4 by testing them on tissues known to express DTX4 positively and negatively. Browse below to find the DTX4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DTX4 Infographic by Boster Bio

All DTX4 Products

Product

Figures

Specificity

Applications

Price

Anti-DTX4 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A12829
0.1 mg

DTX4 (NM_015177) Human Over-expression Lysate

Human

$960
Cat # LS023220
100 µg

DTX4 Overview

Facts about E3 ubiquitin-protein ligase DTX4.

DTX4 3D structure. Source: alphafold

E3 ubiquitin-protein ligase DTX4 (DTX4)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.

Gene Information

Human
Gene Name:	DTX4
Uniprot:	Q9Y2E6
Entrez:	23220

Family

Belongs to:

Deltex family

Alternative Names

Deltex 4 Homolog (Drosophila); Deltex 4 Homolog; Deltex Homolog 4 (Drosophila); deltex4; DTX4; E3 Ubiquitin-Protein Ligase DTX4; EC 6.3.2.; KIAA0937; Protein Deltex-4; RING Finger Protein 155; RNF155

Molecular Weight

Mass (kDA):
67.258 kDA

Genomic Context


Human

Location:	11q12.1
Sequence:	11; NC_000011.10 (59171430..59208588)

Subcellular Localizations

Cytoplasm.

Diseases

Multiple Myeloma
Malignant Neoplasms
Colorectal Neoplasms
Tissue Adhesions
Colorectal Cancer

Pathways

Cell Adhesion
Translation
Immune Response

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DTX4

References

PMID: 15684394 by Storck S., et al. Normal immune system development in mice lacking the Deltex-1 RING finger domain.

PMID: 22388039 by Cui J., et al. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.