DTX3L Antibodies

AND DTX3L ELISA kits, DTX3L Proteins

Many biological assays use antibodies to detect DTX3L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DTX3L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DTX3L antibodies...

We validate the specificity of these antibodies to DTX3L by testing them on tissues known to express DTX3L positively and negatively. Browse below to find the DTX3L antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DTX3L Infographic by Boster Bio

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DTX3L (NM_138287) Human Over-expression Lysate

Human

$628
Cat # LS151636
100 µg

DTX3L Overview

Facts about E3 ubiquitin-protein ligase DTX3L.

DTX3L 3D structure. Source: alphafold

E3 ubiquitin-protein ligase DTX3L (DTX3L)

E3 ubiquitin-protein ligase that, in conjunction with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742).

The specific role of H4K91ub1 in DNA damage response is still unclear but it may be a licensing signal for additional histone H4 post-translational modifications such as H4'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272).

Gene Information

Human
Gene Name:	DTX3L
Uniprot:	Q8TDB6
Entrez:	151636

Family

Belongs to:

Deltex family

Alternative Names

BBAPEC 6.3.2.-; B-lymphoma- and BAL-associated protein; deltex 3-like (Drosophila); E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; rhysin 2; rhysin2; Rhysin-2

Molecular Weight

Mass (kDA):
83.554 kDA

Genomic Context


Human

Location:	3q21.1
Sequence:	3; NC_000003.12 (122564338..122575203)

Subcellular Localizations

Cytoplasm. Nucleus. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM (PubMed:24790097). A minor proportion localizes to lysosomes (PubMed:24790097).

Diseases

Lymphoma
B-cell Lymphomas
Diffuse Large B-cell Lymphoma
Adenocarcinoma
Malignant Squamous Cell Neoplasm
Uterine Cervical Neoplasm
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Malignant Tumor Of Cervix
Inflammatory Response
Aggressive Non-hodgkin Lymphoma

Carcinoma
Malignant Neoplasms
Neoplasms
Papillomavirus Infections
Cytogenetic Abnormality

Interacting Proteins

SPG21

Pathways

Localization
Cell Adhesion
Dna Repair
Inflammatory Response
Chromatin Remodeling

PTMs

Acetylation

Phosphoprotein

Ubl conjugation

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DTX3L

References

PMID: 12670957 by Takeyama K., et al. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

PMID: 16809771 by Juszczynski P., et al. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate.