DTX1 Antibodies

AND DTX1 ELISA kits, DTX1 Proteins

Many biological assays use antibodies to detect DTX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DTX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DTX1 antibodies...

We validate the specificity of these antibodies to DTX1 by testing them on tissues known to express DTX1 positively and negatively. Browse below to find the DTX1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DTX1 Infographic by Boster Bio

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DTX1 Overview

Facts about E3 ubiquitin-protein ligase DTX1.

DTX1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase DTX1 (DTX1)

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.

Mainly acts as a positive regulator of Notch, but in addition, it acts as a negative regulator, based on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1.

Gene Information

Human
Gene Name:	DTX1
Uniprot:	Q86Y01
Entrez:	1840

Family

Belongs to:

Deltex family

Alternative Names

deltex homolog 1 (Drosophila); Deltex1; DTX1; Dx-1; hDTX1; hDx-1; protein deltex-1

Molecular Weight

Mass (kDA):
67.368 kDA

Genomic Context


Human

Location:	12q24.13
Sequence:	12; NC_000012.12 (113056711..113098028)

Tissue Specificity

Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.