This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Dysbindin Antibodies
AND DTNBP1 ELISA kits, Dysbindin Proteins
Many biological assays use antibodies to detect Dysbindin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dysbindin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dysbindin antibodies...
Previous: Septin9
Next: KIRREL2
DTNBP1 Infographic by Boster Bio
All DTNBP1 Products
Product
Figures
Specificity
Applications
Price
DTNBP1 Overview
Facts about Dysbindin.
Dysbindin (DTNBP1)
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complicated, the BLOC-1 complicated is required to target membrane protein cargos into vesicles constructed at cell bodies for delivery into neurites and nerve terminals.
The BLOC-1 complicated, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complicated to facilitate the transfer of TYRP1 independent of AP-3 function.
Gene Information
| Human | |
|---|---|
| Gene Name: | DTNBP1 |
| Uniprot: | Q96EV8 |
| Entrez: | 84062 |
Family
| Belongs to: |
|---|
| dysbindin family |
Alternative Names
DKFZp564K192; dysbindin; dysbindin-1; dystrobrevin binding protein 1; Dystrobrevin-binding protein 1; FLJ30031; Hermansky-Pudlak syndrome 7 protein; HPS7 protein; HPS7DBND; MGC20210; My031; SDY
Molecular Weight
Mass (kDA):
39.493 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p22.3 |
| Sequence: | 6; NC_000006.12 (15522803..15663058, complement) |
Tissue Specificity
Detected in brain, in neurons and in neuropil. Isoform 1 is expressed in the cerebral cortex, and hippocampal frontal (HF). Specific expression in the posterior half of the superior temporal gyrus (pSTG). Higher expression of isoform 2 and 3 in the HF than in the pSTG while isoform 1 shows no difference in expression in these areas. In the HF, detected in dentate gyrus (DG) and in pyramidal cells of hippocampus CA2 and CA3 (at protein level). Expressed in all principal neuronal populations of the HF, namely pyramidal neurons in the subiculum and CA1-3, granule cells in the dense cell layer of the DG (DGg), and polymorph cells in the hilus of the DG (DGh). Maximal levels in CA2, CA3, and DGh. Isoform 2 not expressed in the cerebral cortex.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Endoplasmic reticulum. Nucleus. Mainly cytoplasmic but shuttles between the cytoplasm and nucleus. Exported out of the nucleus via its NES in a XPO1-dependent manner. Nuclear localization is required for regulation of the expression of genes such as SYN1. Detected in neuron cell bodies, axons and dendrites. Mainly loc
Diseases
- Schizophrenia
- Psychotic Disorders
- Mental Disorders
- Bipolar Disorder
- Dysequilibrium Syndrome
- Malnutrition
- Impaired Cognition
- Cognition Disorders
- Depressive Disorder
- Anxiety Disorders
- Mood Disorders
- Schizoaffective Disorder
Interacting Proteins
- BLOC1S1
- BLOC1S2
- BLOC1S3
- BLOC1S5
- BLOC1S6
- BRK1
- CCDC153
- DTNB
- ELOVL7
- HAUS1
Pathways
- Pathogenesis
- Cognition
- Synaptic Transmission
- Localization
- Exocytosis
- Brain Development
- Prepulse Inhibition
- Habituation
- Endocytosis
- Long-term Memory
- Membrane Fusion
- Transport
- Pigmentation
PTMs
- Phosphorylation
- Biotinylation
- Reduction
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DTNBP1
bosterbio.com/bosterbio-gene-info-cards/DTNBP1
References
PMID: 12923531 by Li W., et al. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
PMID: 15345706 by Numakawa T., et al. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia.