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DTL Antibodies
AND DTL ELISA kits, DTL Proteins
Many biological assays use antibodies to detect DTL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DTL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DTL antibodies...
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DTL Infographic by Boster Bio
All DTL Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01255
100 μl
Cat # M01255
100 μl
DTL Overview
Facts about Denticleless protein homolog.
Denticleless protein homolog (DTL)
The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is vital to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480).
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is imperative to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important to get a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445).
Gene Information
| Human | |
|---|---|
| Gene Name: | DTL |
| Uniprot: | Q9NZJ0 |
| Entrez: | 51514 |
Family
| Belongs to: |
|---|
| WD repeat cdt2 family |
Alternative Names
CDT2RA-regulated nuclear matrix-associated protein; CDW1; DCAF2DDB1 and CUL4 associated factor 2; DDB1- and CUL4-associated factor 2; denticleless homolog (Drosophila); L2DTLRA regulated nuclear matrix associated protein; Lethal(2) denticleless protein homolog; RAMPdenticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein
Molecular Weight
Mass (kDA):
79.468 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.3 |
| Sequence: | 1; NC_000001.11 (212035553..212105013) |
Tissue Specificity
Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Subcellular Localizations
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Diseases
- Disease Of Adrenal Medulla
- Neoplasms
- Malignant Neoplasms
- Glaucoma
- Carcinoma
- Corneal Diseases
- Retinal Diseases
- Flasher - Visual Manifestation
- Retinitis Pigmentosa
- Glaucoma, Open-angle
- Intraocular Pressure Disorder
- Macule
Interacting Proteins
- DDB1
Pathways
- Cell Cycle
- S Phase
- Transport
- Localization
- Dna Replication
- Proteolysis
- Cell Proliferation
- Mitosis
- Cytokinesis
- Interphase
- Urea Transport
- Cell Cycle Arrest
- Water Transport
PTMs
- Ubiquitination
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DTL
bosterbio.com/bosterbio-gene-info-cards/DTL
References
PMID: 11278750 by Cheung W.M., et al. Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation.
PMID: 16861906 by Higa L.A., et al. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.