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- Table of Contents
Facts about Dermatan-sulfate epimerase.
Human | |
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Gene Name: | DSE |
Uniprot: | Q9UL01 |
Entrez: | 29940 |
Belongs to: |
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dermatan-sulfate isomerase family |
Chondroitin-glucuronate 5-epimerase; dermatan sulfate epimerase; dermatan-sulfate epimerase; DSEPI; EC 5.1.3.19; SART-2; SART2DS epimerase; squamous cell carcinoma antigen recognized by T cells 2; Squamous cell carcinoma antigen recognized by T-cells 2
Mass (kDA):
109.773 kDA
Human | |
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Location: | 6q22.1 |
Sequence: | 6; NC_000006.12 (116254171..116444861) |
Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level).
Membrane; Multi-pass membrane protein.
PMID: 10679095 by Nakao M., et al. Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL.
PMID: 16505484 by Maccarana M., et al. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5- epimerase is identical to SART2.