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D(3) dopamine receptor Antibodies
AND DRD3 ELISA kits, D(3) dopamine receptor Proteins
Many biological assays use antibodies to detect D(3) dopamine receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with D(3) dopamine receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop D(3) dopamine receptor antibodies...
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DRD3 Infographic by Boster Bio
All DRD3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1584
100 μg/vial
Cat # PA1584
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # M01277
100 μl/vial
Cat # M01277
100 μl/vial
DRD3 Overview
Facts about D(3) dopamine receptor.
D(3) dopamine receptor (DRD3)
Dopamine receptor whose activity is mediated by G proteins that inhibit adenylyl cyclase. Promotes cell proliferation.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | DRD3 |
| Uniprot: | P35462 |
| Entrez: | 1814 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
D(3) dopamine receptor; D3DR; Dopamine D3 R; Dopamine D3 receptor; Dopamine D3R; dopamine receptor D3; DRD3; essential tremor 1; ETM1; FET1; MGC149204; MGC149205
Molecular Weight
Mass (kDA):
44.225 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q13.31 |
| Sequence: | 3; NC_000003.12 (114127580..114199407, complement) |
Tissue Specificity
Brain.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
Diseases
- Schizophrenia
- Parkinson Disease
- Dyskinetic Syndrome
- Psychotic Disorders
- Depressive Disorder
- Mental Disorders
- Bipolar Disorder
- Lingual-facial-buccal Dyskinesia
- Dysequilibrium Syndrome
- Dyskinesia, Drug-induced
- Variable Number Tandem Repeat
Pathways
- Locomotion
- Pathogenesis
- Localization
- Sensitization
- Secretion
- Cognition
- Dopamine Uptake
- Transport
- Innervation
- Prolactin Secretion
- Brain Development
- Reverse Transcription
- Excretion
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DRD3
bosterbio.com/bosterbio-gene-info-cards/DRD3
References
PMID: 2129115 by Giros B., et al. Gene cloning of human dopaminergic D3 receptor and identification of its chromosome.
PMID: 8415635 by Schmauss C., et al. Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia.