DPYD Antibodies

Dihydropyrimidine dehydrogenase [NADP(+)] (DPYD)

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. .

Gene Information

Human
Gene Name:	DPYD
Uniprot:	Q12882
Entrez:	1806

Family

Belongs to:
dihydropyrimidine dehydrogenase family

Alternative Names

DHP; DHPDHASE; dihydropyrimidine dehydrogenase [NADP+]; dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPDMGC132008; EC 1.3.1.2; MGC70799

Molecular Weight

Mass (kDA):
111.401 kDA

Genomic Context

Human
Location:	1p21.3
Sequence:	1; NC_000001.11 (97077743..97921059, complement)

Tissue Specificity

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Dihydropyrimidine Dehydrogenase Deficiency
• Colorectal Neoplasms
• Colorectal Cancer
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Carcinoma
• Adenocarcinoma
• Mucositis
• Diarrhea
• Stomach Neoplasms
• Medication Reaction
• Malignant Neoplasm Of Breast

• Malignant Neoplasm Of Stomach
• Rheumatoid Arthritis
• Arthritis
• Malignant Tumor Of Colon
• Pain
• Osteoporosis
• Neoplasm Metastasis

Interacting Proteins

• GOPC
• LXN

Pathways

• Bone Resorption
• Excretion
• Methylation
• Dna Repair
• Cell Cycle
• Pathogenesis
• Dna Methylation
• Menopause
• Translation
• S Phase
• Transport
• Immune Response
• Neurogenesis

• Response To Drug
• Demethylation
• Flight
• Sensitization
• Response To 5-fluorouracil
• Drug Transport
• Cell Death

PTMs

• Methylation

• Demethylation

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DPYD

Boster Bio: Best Uses Of The DPYD Marker

If you're looking for high-affinity primary antibodies, Boster is the company for you. Their antibodies are validated for Western Blotting, Immunohistochemistry, and ELISA. They are frequently cited in the research community. They are also readily available online at an affordable price. The bio of Boster contains more information.

Boster offers high-affinity prim antibodies

A diabode, one type of antibody against this target, is available. This antibody is composed of two antigen binding sites. The linkers that connect the two antigenbinding domains in a polypeptide molecule chain are too short and cannot allow pair-wise pairing between identical domains. Instead, they force the antigen binding domains to pair up with complementary domains in another chain.

The polypeptide linker between the VL and H chains of a polypeptide antibody is necessary to enable the scFv to form the specific structure for binding to the antigen. The antigen is an immunogenic protein or carbohydrate, or nucleic acids. Antibodies are monoclonal and polyclonal as well as multivalent.

History of Steven Boster

Steven Boster made his family his top priority. He was the one who called when his car stopped working at 2 a.m. and he was there if it started to snow. He loved auto racing and sports and was not likely to miss a Friday night game. He was famous for showing up at appointments in subzero temperature. Steven Boster is a man of many landmarks.

Steve Boster was a Joliet native. He was the son of James and Evelyn Meier Boster. He had been a retail sales manager for years and was a member of Concordia Hall of Staunton. His two daughters, Crystal Boster and Natosha Peck, are his survivors. He also has 6 grandchildren. His mother Frances, his brother Jack, sister Tammy, and sister Kimberly are his survivors.

Primary antibodies of high-affinity

Humanized antibodies of the present invention are made from polypeptide fragments containing V H and V L domains and a polypeptide linker. These fragments have been designed to form antigen binding structures. Antigens are proteins, carbohydrates, or nucleic acids. An epitope is the portion of the antigen that a polypeptide antibody recognizes.

Since decades, DPYD marker-derived antibodies have been produced. Several chromatographic techniques are used to purify DPYD-marker-derived antibody, such as mouse antiTEM8, from various chromatographic techniques. Modern research has been dominated by DPYD marker-derived antibodies. In recent years, the DPYD indicator has become an indispensable tool for antibody production.

Human antigens are typically isolated from their natural resources. DPYD antigens contain the nucleic molecule in cells that express the antibody. This is called affinity-matured antibody manufacturing. Affinity-matured antibodies have nanomolar affinities to the target antigen. They can also been produced in a standard way. These antibodies have two main types: antagonist and blocking. They inhibit the biological activity of the antigen and reduce or eliminate its effects.

The present invention contains humanized antibodies. These antibodies are made up of heavy and lighter chains of a human immuneglobulin. They may also contain an antigen-specific DNA fragment. Chimeric antibodies are also known to be humanized antibodies. These chimeric antibodies may have fragments from different classes or species of antibodies. They were filed with ATCC on Jun. 8, 2011. 8.11.

Phage display Libraries are created to produce monoclonal antibodies. The phage that carries a particular antigen binding domain is chosen. The resulting antigen-binding particle is then used to infect a fresh bacterial cell line. This results is the production of monoclonal antibodies with the desired antigenbinding properties. This is commonly referred to by the term "panning".

These monoclonal antibodies have been developed to recognize TEM8. They can be used to treat or prevent diseases caused by abnormal vascular proliferation. These antibodies can target these cells selectively by binding to TEM8. The project was carried out using two cell lines: KR12, which is a mouse fusion companion, and CHO/TEM8, which is a human meeloma cell cell line.