Protein Dok-7 Antibodies

Protein Dok-7 (Dok7)

Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes.

Induces autophosphorylation of MUSK. .

Gene Information

Mouse
Gene Name:	Dok7
Uniprot:	Q18PE0
Entrez:	231134

Family

Belongs to:
No superfamily

Alternative Names

C4orf25; C4orf25chromosome 4 open reading frame 25; CMS1B; docking protein 7; DOK7; Dok-7; Downstream of tyrosine kinase 7; FLJ33718; FLJ39137; FLJ90556; protein Dok-7

Molecular Weight

Mass (kDA):
53.177 kDA

Genomic Context

Mouse
Location:	5|5 B2
Sequence:	5;

Diseases

• Myasthenic Syndromes, Congenital
• Weakness
• Myasthenias
• Muscle Weakness
• Myasthenia Gravis
• Autoimmune Reaction
• Autoimmune Diseases
• Blepharoptosis
• Muscular Dystrophies, Limb-girdle
• Myopathy
• Malignant Neoplasms

• Neoplasms
• Stridor
• Mycoplasma Pneumonia
• Pena-shokeir Syndrome Type I
• Gait Disorders, Neurologic

Pathways

• Localization
• Pathogenesis
• Muscle Contraction
• Dna Hypermethylation
• Aging
• Dna Methylation
• Synaptic Transmission
• Muscle Atrophy
• Nuclear Export
• Methylation
• Regeneration

• System Development
• Nervous System Development
• Skeletal Muscle Contraction
• Segmentation
• Innervation
• Nuclear Import

PTMs

• Phosphorylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dok7

Boster Bio - Best Uses Of The DOK7 Marker

In this article, we'll examine the benefits and uses of Boster Bio's DOK7 Antibody. The company says its product is useful for species, applications, and special samples. It will also give scientists product credits for their results. This is applicable to all scientists worldwide, regardless of the size of their organization. But how do we know if it will be a useful tool for us?

Boster Bio Anti-Protein Dok-7 DOK7 Antibody

Known as the Docking protein 2, this tyrosine kinase receptor functions in feedback loops to regulate tyrosine kinaser signaling. In addition to regulating tyrosine kinase signaling, DOK7 is also involved in the regulation of the activities of c-Kit and Tie2. This antibody has potential to identify the presence of DOK7 in colorectal cancer.

This high quality monoclonal Dok-7 DOK7 antibody is ideal for the detection of the Dok-7 protein from mouse samples. This product is available as both conjugated and non-conjugated forms. In addition to its monoclonal anti-Dok-7 antibody, it is available in multiple Alexa Fluor(r) conjugated forms. It recognizes Dok-7, a member of the docking protein family that contains multiple tyrosine residues and putative SH2 binding sites.

Detection of Dok2 and RASA1 is associated with breast cancer progression, recurrence, and poor survival rate. The combined detection of these two proteins may serve as an effective prognostic tool and novel therapeutic target for breast cancer. It was funded by the Hubei Province's Nature Science Foundation, Yangtze University Medical School Youth Fund, and Yangtze University.