DOCK6 Antibodies

AND DOCK6 ELISA kits, DOCK6 Proteins

Many biological assays use antibodies to detect DOCK6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOCK6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOCK6 antibodies...

We validate the specificity of these antibodies to DOCK6 by testing them on tissues known to express DOCK6 positively and negatively. Browse below to find the DOCK6 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DOCK6 Infographic by Boster Bio

All DOCK6 Products

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Price

Dedicator of cytokinesis protein 6 (DOCK6) (NM_020812) Human Over-expression Lysate

Human

$960
Cat # LS057572
100 µg

DOCK6 Overview

Facts about Dedicator of cytokinesis protein 6.

DOCK6 3D structure. Source: alphafold

Dedicator of cytokinesis protein 6 (DOCK6)

Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).

Gene Information

Human
Gene Name:	DOCK6
Uniprot:	Q96HP0
Entrez:	57572

Family

Belongs to:

DOCK family

Alternative Names

AOS2; Dedicator Of Cytokinesis 6; Dedicator Of Cytokinesis Protein 6; KIAA1395; ZIR1

Molecular Weight

Mass (kDA):
229.558 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (11199295..11262524, complement)

Tissue Specificity

Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.

Subcellular Localizations

Cytoplasm. Cytoplasm, perinuclear region. Mainly located near the cell surface.

Diseases

Hyperpigmentation
Limb Deformities, Congenital
Neuroblastoma
Scalp Dermatoses
Limb Defect
Hepatitis
Hypoxia
Gastric Ulcer
Hepatitis C
Edema
Aplasia Cutis Congenita

Ectodermal Dysplasia
Pain
Shwachman Syndrome
Aplasia, Nos
Anoxia
Adams Oliver Syndrome

Pathways

Actin Cytoskeleton Organization
Cytoskeleton Organization
Protein Folding
Pathogenesis
Cytokinesis

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOCK6

References

PMID: 12432077 by Cote J.-F., et al. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity.

PMID: 17196961 by Miyamoto Y., et al. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth.