Dnd1 Antibodies

AND Dnd1 ELISA kits, Dnd1 Proteins

Many biological assays use antibodies to detect Dnd1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dnd1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dnd1 antibodies...

We validate the specificity of these antibodies to Dnd1 by testing them on tissues known to express Dnd1 positively and negatively. Browse below to find the Dnd1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Dnd1 Infographic by Boster Bio

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Dnd1 Overview

Facts about Dead end protein homolog 1.

Dead end protein homolog 1 (Dnd1)

RNA-binding factor that positively regulates gene expression by banning miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity).

Prohibits the function of many miRNAs by blocking the availability of target mRNAs (By similarity). Sequence- specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity).

Gene Information

Mouse
Gene Name:	Dnd1
Uniprot:	Q6VY05
Entrez:	213236

Family

Belongs to:

No superfamily

Alternative Names

dead end homolog 1 (zebrafish); dead end protein homolog 1; RBMS4MGC34750; RNA-binding motif, single-stranded-interacting protein 4

Molecular Weight

Mass (kDA):
39.076 kDA

Genomic Context


Mouse

Location:	18 B2\|18 19.46 cM
Sequence:	18;

Tissue Specificity

Isoform 1 and isoform 2 are expressed in testis. Isoform 1 is expressed continuously in post natal (PN) testis although levels are low between PN1 to PN6. Isoform 2 is expressed from PN 20 onwards. Isoform 2 is strongly expressed in meiotic and in post-meiotic germ cells of the testis with highest expression at the elongated spermatid stage (at protein level). Expressed in testis and heart. Expressed in germ cells and genital ridges. Not detected in testicular tumors.

Diseases

Neoplasms
Germ Cell Tumor
Testicular Neoplasms
Neoplasms, Germ Cell And Embryonal
Testicular Germ Cell Tumor
Teratoma
Malignant Neoplasms
Plant Diseases
Cell Transformation, Neoplastic
Sterility
Carcinoma
Malignant Neoplasm Of Testis
Embryonal Carcinoma

Infertility
Ovarian Neoplasm
Testicular Dysplasia
Congenital Abnormality
Tongue Neoplasms
Dementia
Tongue Squamous Cell Carcinoma

Pathways

Cell Death
Disease Resistance
Cell Development
Defense Response
Germ Cell Development
Programmed Cell Death
Cell Cycle
Senescence
Photosynthesis
Immune Response
Cell Cycle Arrest
Spermatogenesis
Embryo Development

Sensitization
Innate Immune Response
Regulation Of Cell Cycle
Cell Proliferation
Mitosis
Metaphase
Oocyte Maturation

PTMs

Methylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dnd1

References

PMID: 12932328 by Weidinger G., et al. Dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival.

PMID: 15902260 by Youngren K.K., et al. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.