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Dystrophin Antibodies
AND DMD ELISA kits, Dystrophin Proteins
Many biological assays use antibodies to detect Dystrophin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dystrophin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dystrophin antibodies...
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DMD Infographic by Boster Bio
All DMD Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # PB9276
100 μg/vial
Cat # PB9276
100 μg/vial
DMD Overview
Facts about Dystrophin.
Dystrophin (DMD)
Anchors the extracellular matrix to the cytoskeleton via F-actin.
Ligand for dystroglycan.Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
Gene Information
| Human | |
|---|---|
| Gene Name: | DMD |
| Uniprot: | P11532 |
| Entrez: | 1756 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BMDDXS272; CMD3B; DXS142; DXS164; DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142; dystrophin
Molecular Weight
Mass (kDA):
426.75 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp21.2-p21.1 |
| Sequence: | X; NC_000023.11 (31119219..33339460, complement) |
Tissue Specificity
Expressed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma. Expressed in brain, muscle, kidney, lung and testis. Isoform 5 is expressed in heart, brain, liver, testis and hepatoma cells. Most tissues contain transcripts of multiple isoforms, however only isoform 5 is detected in heart and liver.
Subcellular Localizations
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals.
Diseases
- Muscular Dystrophy
- Dystrophy
- Muscular Dystrophy, Duchenne
- Becker Muscular Dystrophy
- Muscular Dystrophy, Animal
- Myopathy
- Neuromuscular Diseases
- Cardiomyopathies
- Weakness
- Fibrosis
- Muscular Atrophy
- Muscle Weakness
Interacting Proteins
- ANK2
- CTNNAL1
- DISC1
- DTNB
- HAUS1
- KRT19
- SNTB1
- SNTB2
Pathways
- Regeneration
- Localization
- Pathogenesis
- Methylation
- Translation
- Immune Response
- Dna Methylation
- Transport
- Fermentation
- Excretion
- Muscle Atrophy
- Cell Death
- Reverse Transcription
PTMs
- Methylation
- Oxidation
- Phosphorylation
- Cleavage
- Demethylation
- Phosphorothioation
Research Areas
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DMD
bosterbio.com/bosterbio-gene-info-cards/DMD
References
PMID: 3282674 by Koenig M., et al. The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein.
PMID: 2668885 by Rosenthal A., et al. Two human cDNA molecules coding for the Duchenne muscular dystrophy (DMD) locus are highly homologous.