Homeobox protein DLX-2 Antibodies

Homeobox protein DLX-2 (DLX2)

Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina.

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Gene Information

Human
Gene Name:	DLX2
Uniprot:	Q07687
Entrez:	1746

Family

Belongs to:
distal-less homeobox family

Alternative Names

distal-less homeo box 2; distal-less homeobox 2; homeobox protein DLX-2; TES1; TES-1

Molecular Weight

Mass (kDA):
34.243 kDA

Genomic Context

Human
Location:	2q31.1
Sequence:	2; NC_000002.12 (172099438..172102900, complement)

Subcellular Localizations

Nucleus.

Diseases

• Crest Syndrome
• Nervousness
• Neoplasms
• Congenital Abnormality
• Malignant Neoplasms
• Autistic Disorder
• Dysplasia
• Cleft Palate
• Hypodontia
• Craniofacial Abnormalities
• Congenital Camptodactyly
• Syndactyly

• Epilepsy
• Hypoplasia
• Leukemia
• Melanoma
• Ectrodactyly
• Pituitary Diseases

Interacting Proteins

• GRN

Pathways

• Neurogenesis
• Cell Cycle
• Cell Differentiation
• Cell Proliferation
• Brain Development
• Localization
• Forebrain Development
• Cell Migration
• Odontogenesis
• Segmentation
• Pathogenesis
• Limb Development
• Cell Division

• Gliogenesis
• Neuron Differentiation
• Osteoblast Differentiation
• Cell-cell Adhesion
• Regeneration
• Innervation
• Tissue Homeostasis

PTMs

• Phosphorylation
• Methylation

• Cleavage
• Acetylation

• Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLX2

Boster Bio - Best Uses Of The DLX2 Marker

What is the DLX2? What can it do to aid your research? This article will discuss the Molecular Target as well as its Clinical Applications. Additionally, you'll discover more about how Boster Bio has made this marker part of its testing procedure. If you're interested in DLX2 then read on! It's a highly effective biomarker that provides you with the results from thousands of clinical trials.

DLX2

The DLX2 marker is a cell transcription factor that is activated by the oligomer DNMT1. This gene regulates the activity of Nkx2-1 an important transcription factor which plays a crucial role in controlling the expression of Dlx2. It has been found that DNMT1 and DNMT2 are closely linked with the expression of DNMT2 and DLX2 which are two of the major components of chromatin in cells.

DLX2 is regarded as a universal marker for GABAergic interneuron precursors. It was utilized in an earlier study to determine the relative contribution of CGE and MGE to the cortical inneruron population. Double-labeled DLX2+ cells with COUP-TFII and LHX6 were utilized to identify MGE-derived interneurons and CGE-derived interneurons. However, a significant proportion of these cells did not co-express COUP-TFII or DLX2 at 8 PCW.

Molecular Target

The Molecular Target Of The DLX2 marker regulates the growth of branchial arches within vertebrates. In humans, DLX2 has been implicated in the development of a variety of neurodevelopmental disorders. Two autism susceptibility loci have members of the Dlx family. The Dlx and Arx genes share common molecular targets and transcriptional cascades.

The DLX2 gene is involved in the shift of TGFb from the tumour suppressor to tumor promoter. It inhibits TGFbRII and the cell-cycle inhibitor, p21CIP1. It also blocks the activity of transcription factors that are involved in cell adhesion as well as migration. These features could explain why DLX2 is linked to an increase in metastasis risk.

The Dlx gene regulates the timing of GABAergic cell migration and the formation. The gene is highly expressed and results in a cell-autonomous effect. This could also explain the significance of Dlx genes in the timing of GABAergic cell movement and process formation. Further research is required to determine whether Dlx2 is the biomarker of choice. This approach could lead to an advancement in diagnosing prostate cancer and in treating it.

The Molecular Target Of The DLX2 marker is involved in the formation of the neural crest. The neural plate is part of the embryonic ectoderm , which forms the neural crest. The transcription factors of the Dlx gene group control cell fate in the neural plate. In addition, this transcription factor could also control the development of the neural crest. This gene could be a potential target for drugs that target the Dlx gene.

The Dlx2 gene encodes an transcription factor that has two recognizable binding module. They don't meet the Dlx consensus binding requirements. It is interesting to note that Dlx proteins are also required for transcription of the Arx gene. However, other homeodomain-containing proteins normally expressed in the ventral telencephalon have not been found to activate the Arx enhancer. While Arx expression is not decreased in Dlx2 mutants, it is much lower than that of wild type.

The Molecular Target of the Marker DLX2 is a major player in GABAergic cell fate determinations. GAD65 expression is activated through the gene Dlx in cortical progenitors. Moreover, ectopic expression of the gene Dlx2 stimulates LacZ gene activity. The activation of the Arx gene is blocked by the truncated BMP-4 receptor, while Dlx activates it.

Dlx proteins regulate a range of aspects of GABAergic neuron growth. Dlx1/2 proteins play a role in the identification of a later set of subpallidal neuron precursors. They play an important role in the fate of GABAergic neurons by reducing Notch signaling and encouraging the formation GABAergic neurons. They also reduce Olig2 expression and promote the movement of interneurons.

Clinical Applications

The current study has revealed that the DLX2 genes were expressed in the MC3T3E1 cell. The over-expression of DLX2 genes induced osteogenic differentiation. This is due to DLX2-mediated downregulation of the genes ALP2 as well as MSX2. Future studies will examine the osseointeractions of these two genes as well as the role of TGF-b signalling pathways. These findings could be used in clinical applications of bone mesenchymal-derived stem cells that have been transduced by DLX2.

These studies suggest that DLX2 is crucial in autism, which is characterized by hippocampus-related disorders. DLX genes are members of the homeobox transcription factor family and play a role in the development of the forebrain. Although DLX2 may be a marker for autism, there isn't any evidence to suggest it is a cause.

This study was carried out using a Z2 cell count as well as the primer restriction enzyme and anti-DLX2 antibodies. Becker Coulter, Brea, CA, USA, purchased the Z2 cell counter. We used the T4 ligase to combine the pMSCV-puro and the DLX2 fragments. These cells and mice were also subject to immunofluorescence studies.

The genome sequence of the DLX1/DLX2 gene is 30kb. The region was covered by an analysis of Tag SNPs which included a sample of the AGRE of MPX families. The study also included families who were recruited through the ASD-CARC research registry, as well as collaborating clinical geneticists' clinics. The study also contains a significant number of confirmed ASD cases.

The DLX2 gene is a divergent member of the Hox gene family, is a gene. It is vital in the regulation of organism growth. It is associated with the pre-implantation embryo susceptibility pathway and has been linked to dental fluorosis. The gene is associated with DNA-binding transcription factor activation. DLX2 overexpression in MC3T3T3-E1 cells enhances osteogenesis.