Delta-like protein 3 Antibodies

Delta-like protein 3 (DLL3)

Inhibits primary neurogenesis. May be required to divert neurons along a particular differentiation pathway.

Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). .

Gene Information

Human
Gene Name:	DLL3
Uniprot:	Q9NYJ7
Entrez:	10683

Family

Belongs to:
No superfamily

Alternative Names

delta (Drosophila)-like 3; Delta3; delta-like 3 (Drosophila); delta-like protein 3; DLL3; Drosophila Delta homolog 3; Pudgy; SCDO1; SCDO1delta3

Molecular Weight

Mass (kDA):
64.618 kDA

Genomic Context

Human
Location:	19q13.2
Sequence:	19; NC_000019.10 (39498947..39508469)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Dysostoses
• Jarcho-levin Syndrome
• Neoplasms
• Malignant Neoplasms
• Scoliosis, Unspecified
• Congenital Abnormality
• Glioma
• Nervousness
• Brain Neoplasms
• Dysplasia
• Congenital Heart Defects
• Diaphragmatic Hernia

• Carcinoma
• Spondylocostal Dysostosis, Autosomal Recessive
• Tumor Angiogenesis
• Malignant Paraganglionic Neoplasm
• Hereditary Diseases
• Cell Transformation, Neoplastic
• Glioblastoma

Pathways

• Segmentation
• Somitogenesis
• Notch Signaling Pathway
• Neurogenesis
• Cell Differentiation
• Cell Development
• Localization
• Angiogenesis
• Brain Development
• Ossification
• Vasculogenesis
• Cell Fate Specification
• Gliogenesis

• Cell Cycle
• Endocytosis
• Regeneration
• Cell Activation
• Developmental Process
• Stem Cell Maintenance
• Proteolysis

PTMs

• Phosphorylation

• Methylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLL3

Boster Bio - Best Uses Of The DLL3 Marker

Boster Bio is the first choice for scientists looking for high-affinity prima antibodies. Boster Bio provides high-affinity antibodies for DLL3 (and its ligands). We will be discussing the benefits and uses of these antibodies in this article. In addition, we will discuss the Boster's quality control process. This step ensures that Boster products meet the highest standards of quality.

Boster Bio provides high-affinity primary antibodies

Boster Bio is an antibody manufacturer specializing on picogram-sensitive ELISA tests, IHC-optimized clonal antibodies, and Flow/IHC detection devices. The company offers over 12,000 antibodies validated for use in IHC, WB, and Flow applications. Their products are tested against panels of 250 tissues to ensure high specificity and accuracy. Additionally, Boster Bio validates their antibodies quantitatively with known amounts of recombinant proteins.

The DLL3 reaction was observed in cell lines with low Notch and high NE levels. In addition, all four antibodies showed a positive reaction in the NCIH69s cells line. The VenA antibody stained 95% of smear cells, and 75% in cytoblocks. TherA (novA) and TherA (therA) showed varying degrees of positivity.

Boster offers high-affinity prim antibodies

It is essential that flow cytometry uses highly specific antibodies to detect DLL3-protein in samples. These antibodies are made by the immune systems of host cells and contain a high-specificity and high-affinity peptide sequence. To make primary antibodies, scientists first immunize the host with antigens and then extract the antibodies from their sera. They then purify these antibodies for further analysis.

DLL3 can also be found on the cell surface of SCLC cells. It has also been implicated with the development of neuroendocrine cancers. This makes antibodies against it useful for the development targeted therapies. Boster Bio provides high-affinity primary antibodies against DLL3 marker. This antibody is highly specific. The DLL3 gene is abundant in normal and malignant tissues.

Secondary antibodies can be used as secondary antibodies to label specimens using primary antibodies. This allows researchers the ability to ask more specific questions and generate contextual data that will give them a more solid answer. The high-affinity secondary antibody can also be used for the detection of other markers like CDC25A, AKT1, and CDC25A. These antibodies come in many conjugates, making them easy to use. You can detect and measure DLL3 in many samples as long as you use the exact same antibody.

The DNA of human antibody antibodies is used to construct chimeric antigen expression vectors. The chimeric antigen is produced by fusing two genes in the same frame. These two genes get amplified with PCR. The primers used in PCR are known. The genes can then be transfected into cells that allow for the expression of human antibody. These cells express the genes. These cells can then be used to create antibodies.

The Cg1-Cg4 regions of Boster Bio contain high-affinity primaries antibodies against DLL-3. CDRs have a high homology and are often found in the same regions. Hence, if you need high-affinity antibodies against the DLL3 marker, you can opt for humanized antibodies. They are ideal for immunodiagnosis.

There are many ways to detect DLL3 protein. You can also use other methods to detect it. For example, you can use immunofluorescent technology to detect the protein in tissue samples. A high-affinity antibody can be used in immunohistochemistry. If you want to detect DLL3 protein in a particular tissue sample, Boster Bio offers high-affinity primary antibodies against the DLL3 marker.