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DISC1 Antibodies
AND DISC1 ELISA kits, DISC1 Proteins
Many biological assays use antibodies to detect DISC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DISC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DISC1 antibodies...
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DISC1 Infographic by Boster Bio
All DISC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00750
100 μl/vial
Cat # M00750
100 μl/vial
DISC1 Overview
Facts about Disrupted in schizophrenia 1 protein.
Disrupted in schizophrenia 1 protein (DISC1)
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B action and CTNNB1 abundance.
Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the speed of the process of toddlers integration during adult neurogenesis, such as neuron placement, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A.
Gene Information
| Human | |
|---|---|
| Gene Name: | DISC1 |
| Uniprot: | Q9NRI5 |
| Entrez: | 27185 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C1orf136; DISC1; disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9
Molecular Weight
Mass (kDA):
93.611 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q42.2 |
| Sequence: | 1; NC_000001.11 (231626790..232041272) |
Tissue Specificity
Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic density. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198, PubMed:15797709). Colocalizes with PCNT at the centrosome (PubMed:18955030).
Diseases
- Schizophrenia
- Mental Disorders
- Bipolar Disorder
- Psychotic Disorders
- Depressive Disorder
- Major Depressive Disorder
- Mood Disorders
- Chromosomal Translocation
- Autistic Disorder
- Nervousness
- Schizoaffective Disorder
- Malnutrition
Pathways
- Pathogenesis
- Brain Development
- Neurogenesis
- Cognition
- Localization
- Transport
- Cell Migration
- Prepulse Inhibition
- Rna Interference
- Intracellular Transport
- Myelination
- Cell Proliferation
- Translation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
Research Areas
- Alzheimers Research
- Neurodegeneration
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DISC1
bosterbio.com/bosterbio-gene-info-cards/DISC1
References
PMID: 10814723 by Millar J.K., et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia.
PMID: 12573262 by Taylor M.S., et al. Evolutionary constraints on the Disrupted in Schizophrenia locus.
2 Publications of Boster DISC1 Antibodies & ELISA Kits
- PubMed ID: 10.4049/jimmunol.1600180, Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused ...
- PubMed ID: 32482796, Maskalenko N,Nath S,Ramakrishnan A,Anikeeva N,Sykulev Y,Poenie M.The DISC1-Girdi...
*More publications can be found for each product on its corresponding product page