DIAPH2 Antibodies

AND DIAPH2 ELISA kits, DIAPH2 Proteins

Many biological assays use antibodies to detect DIAPH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DIAPH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DIAPH2 antibodies...

We validate the specificity of these antibodies to DIAPH2 by testing them on tissues known to express DIAPH2 positively and negatively. Browse below to find the DIAPH2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DIAPH2 Infographic by Boster Bio

All DIAPH2 Products

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Product

Figures

Specificity

Applications

Price

Anti-DIA-2 DIAPH2 Antibody

7 Q&As

Human

ELISA, WB

$629
Cat # A07378
100ug

Anti-Protein diaphanous homolog 2 DIAPH2 Antibody

Human, Mouse, Rat

$405
Cat # A07378-1
100ul

Anti-Protein diaphanous homolog 2 DIAPH2 Antibody

Human, Mouse

IHC, WB

$380
Cat # A07378-2
100ul

DIAPH2 (NM_006729) Human Over-expression Lysate

Human

$960
Cat # LS001730
100 µg

DIAPH2 Overview

Facts about Protein diaphanous homolog 2.

DIAPH2 3D structure. Source: alphafold

Protein diaphanous homolog 2 (DIAPH2)

Could be involved in oogenesis. Involved in the regulation of endosome dynamics.

Implicated in a novel signal transduction pathway, where isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. .

Gene Information

Human
Gene Name:	DIAPH2
Uniprot:	O60879
Entrez:	1730

Family

Belongs to:

formin homology family

Alternative Names

DIA2; DIAdiaphanous (Drosophila, homolog) 2; DIAPH2; DIAPH-2; diaphanous homolog 2 (Drosophila); Diaphanous-related formin-2; diaphorase-2; DRF2; POF; POF2; POF2FLJ11167; protein diaphanous homolog 2

Molecular Weight

Mass (kDA):
125.569 kDA

Genomic Context


Human

Location:	Xq21.33
Sequence:	X; NC_000023.11 (96684663..97604997)

Tissue Specificity

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

Subcellular Localizations

[Isoform 3]: Cytoplasm, cytosol. Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

Diseases

Premature Menopause
Ovarian Failure, Premature
Turner Syndrome
Chromosomal Translocation
Tissue Adhesions
Chondrosarcoma
Malignant Neoplasms
Protrusion
Amenorrhea
Cytogenetic Abnormality
Malignant Neoplasm Of Pancreas
Glioblastoma

Neoplasm Metastasis
Melanoma
Carcinoma
Neoplasms
Monosomy
Carcinogenesis
Age Related Macular Degeneration

Pathways

Localization
Cytokinesis
Cell Migration
Menopause
Actin Nucleation
Transport
Virulence
Nuclear Export
Spermatogenesis
Nuclear Transport
Cell Division
Menstruation
Sensitization

Limb Morphogenesis
Cell Motility
Prophase
Meiosis I
Wound Healing
Meiosis
Stress Fiber Assembly

PTMs

Phosphorylation

Glycosylation

Acetylation

Research Areas

Cell Cycle and Replication
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DIAPH2

References

PMID: 9497258 by Bione S., et al. A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility.

PMID: 12577064 by Gasman S., et al. RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase.