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- Table of Contents
Facts about ATP-dependent RNA helicase A.
Unwinds numerous nucleic acid substrates like double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex- helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:9111062, PubMed:10198287).
Human | |
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Gene Name: | DHX9 |
Uniprot: | Q08211 |
Entrez: | 1660 |
Belongs to: |
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DEAD box helicase family |
DDX9ATP-dependent RNA helicase A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNAhelicase II; leukophysin); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; EC 3.6.1; EC 3.6.1.15; EC 3.6.4.13; FLJ17406; leukophysin; LKP; NDH II; NDH2; NDHII; Nuclear DNA helicase II; RHA
Mass (kDA):
140.958 kDA
Human | |
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Location: | 1q25.3 |
Sequence: | 1; NC_000001.11 (182839347..182887982) |
Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleoplasmic shuttling protein (PubMed:10198287, PubMed:16375861, PubMed:10207077, PubMed:9162007). Its nuclear import involves the nucleocytoplasmic transport receptor Importin alpha/Importin beta receptor pathway in a Ran-dependent manner (PubMed:16375861). In interphase, localizes in nuclear stress granules and at perichromatin fibrils and in cytoplasmic ribonucleoprotein granules (PubMed:10198287). Colocalizes with WRN and H2AX at centrosomes in a microtubule-d
PMID: 8344961 by Lee C.-G., et al. Human RNA helicase A is homologous to the maleless protein of Drosophila.
PMID: 8690889 by Abdelhaleem M.M., et al. Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles.