DENND1A Antibodies

AND DENND1A ELISA kits, DENND1A Proteins

Many biological assays use antibodies to detect DENND1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DENND1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DENND1A antibodies...

We validate the specificity of these antibodies to DENND1A by testing them on tissues known to express DENND1A positively and negatively. Browse below to find the DENND1A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DENND1A Infographic by Boster Bio

All DENND1A Products

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DENND1A (NM_024820) Human Over-expression Lysate

Human

$628
Cat # LS057706
100 µg

DENND1A Overview

Facts about DENN domain-containing protein 1A.

DENND1A 3D structure. Source: alphafold

DENN domain-containing protein 1A (DENND1A)

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis via RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 to its active GTP-bound form.

Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).

Gene Information

Human
Gene Name:	DENND1A
Uniprot:	Q8TEH3
Entrez:	57706

Family

Belongs to:

No superfamily

Alternative Names

Connecdenn 1; Connecdenn; DENN/MADD domain containing 1A; FAM31ADENN domain-containing protein 1A; FLJ21129; FLJ38464; KIAA1608connecdenn; Protein FAM31A; RP11-230L22.3

Molecular Weight

Mass (kDA):
110.577 kDA

Genomic Context


Human

Location:	9q33.3
Sequence:	9; NC_000009.12 (123379654..123930158, complement)

Subcellular Localizations

Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane. Associates to membranes via lipid-binding activity.

Diseases

Polycystic Ovary Syndrome
Endocrine System Diseases
Carcinoma, Endometrioid
Hypercholesterolemia
Adenocarcinoma
Nervousness
Endometrial Carcinoma

Endometrial Polyp
Carcinoma

Pathways

Menopause

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DENND1A

References

PMID: 20154091 by Marat A.L., et al. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.

PMID: 20937701 by Yoshimura S., et al. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.