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- Table of Contents
Facts about ATP-dependent RNA helicase DDX3X.
Is involved in a number of steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the specific mechanisms are not known and some functions may be specific for a subset of mRNAs.
Human | |
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Gene Name: | DDX3X |
Uniprot: | O00571 |
Entrez: | 1654 |
Belongs to: |
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DEAD box helicase family |
DBXCAP-Rf; DDX14; DDX3DEAD/H box-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; EC 3.6.1; EC 3.6.4.13; helicase like protein 2; Helicase-like protein 2; HLP2ATP-dependent RNA helicase DDX3X
Mass (kDA):
73.243 kDA
Human | |
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Location: | Xp11.4 |
Sequence: | X; NC_000023.11 (41333308..41364472) |
Cell membrane. Nucleus. Cytoplasm. Cytoplasm, Stress granule. Inflammasome. Cell projection, lamellipodium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Shuttles between the nucleus and the cytosol (PubMed:15507209, PubMed:18636090, PubMed:29899501). Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP (PubMed:15507209, PubMed:18636090, PubMed:18596238). Localizes to nuclear pores on the outer side of the nuclear membrane (PubMed:15507209). In the cytosol, partly colocalizes with mitochondria (PubMed:20127681). At G0, predominantly lo
PMID: 10329544 by Owsianka A.M., et al. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3.
PMID: 9381176 by Lahn B.T., et al. Functional coherence of the human Y chromosome.