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DDX39B Antibodies
AND DDX39B ELISA kits, DDX39B Proteins
Many biological assays use antibodies to detect DDX39B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDX39B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDX39B antibodies...
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DDX39B Infographic by Boster Bio
All DDX39B Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Mouse, Rat
IF, WB
$523
Cat # M03490-1
100 µl
Cat # M03490-1
100 µl
Dog, Human, Monkey, Mouse, Rat
IHC, WB
$523
Cat # M03490
100 µl
Cat # M03490
100 µl
Dog, Human, Monkey, Mouse, Rat
IHC, WB
$523
Cat # M03490-2
100 µl
Cat # M03490-2
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03490-3
100 μl/vial
Cat # M03490-3
100 μl/vial
DDX39B Overview
Facts about Spliceosome RNA helicase DDX39B.
Spliceosome RNA helicase DDX39B (DDX39B)
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex that's believed to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA.
TREX is recruited to spliced mRNAs with a transcription- independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and can be recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to induce subsequent loading of elements like ALYREF/THOC and CHTOP on mRNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | DDX39B |
| Uniprot: | Q13838 |
| Entrez: | 7919 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; EC 3.6.4.13; HLA-B associated transcript 1; HLA-B-associated transcript 1 protein; spliceosome RNA helicase BAT1; UAP56D6S81EBAT1nuclear RNA helicase (DEAD family)
Molecular Weight
Mass (kDA):
48.991 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.33 |
| Sequence: | 6; NC_000006.12 (31530226..31542003, complement) |
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasm. Can translocate to the cytoplasm in the presence of MX1. TREX complex assembly seems to occur in regions surrounding nuclear speckles known as perispeckles.
Diseases
- Cytomegalovirus Infections
- Influenza
- Dysequilibrium Syndrome
- Headache
- Rheumatoid Arthritis
- Virus Diseases
- Arthritis
- Cardiomyopathies
- Hypertrophy
- Diabetes Mellitus, Insulin-dependent
- Liver Diseases
- Infarction
- Columnar Cell Change Of The Breast
Interacting Proteins
- ALYREF
- CHTOP
- DDX39A
- RNF4
- SARNP
- SDCBP
Pathways
- Nuclear Export
- Transport
- Localization
- Translation
- Cell Cycle
- Cell Proliferation
- Membrane Fusion
- Rna Splicing
- Immune Response
- Mitosis
- Viral Replication
- Muscle Cell Proliferation
- Golgi Disassembly
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDX39B
bosterbio.com/bosterbio-gene-info-cards/DDX39B
References
PMID: 7601445 by Peelman L., et al. The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family.
PMID: 16702430 by Shiina T., et al. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.