DDX17 Antibodies

AND DDX17 ELISA kits, DDX17 Proteins

Many biological assays use antibodies to detect DDX17, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDX17 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDX17 antibodies...

We validate the specificity of these antibodies to DDX17 by testing them on tissues known to express DDX17 positively and negatively. Browse below to find the DDX17 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DDX17 Infographic by Boster Bio

All DDX17 Products

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Anti-DDX17 Rabbit Monoclonal Antibody

Human, Mouse

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M01656
100 μl/vial

DDX17 Overview

Facts about Probable ATP-dependent RNA helicase DDX17.

DDX17 3D structure. Source: alphafold

Probable ATP-dependent RNA helicase DDX17 (DDX17)

As an RNA helicase, unwinds RNA and changes RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation.

For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). Affects NFAT5 and histone macro-H2A.

Gene Information

Human
Gene Name:	DDX17
Uniprot:	Q92841
Entrez:	10521

Family

Belongs to:

DEAD box helicase family

Alternative Names

DDX17; DEAD (Asp-Glu-Ala-Asp) box polypeptide 17; DEAD box protein 17; DEAD box protein p72; DEAD/H box 17; DKFZp761H2016; EC 3.6.1; EC 3.6.4.13; p72; P72DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD); probable ATP-dependent RNA helicase DDX17; RH70; RNA-dependent helicase p72

Molecular Weight

Mass (kDA):
80.272 kDA

Genomic Context


Human

Location:	22q13.1
Sequence:	22; NC_000022.11 (38483438..38506311, complement)

Tissue Specificity

Widely expressed (PubMed:8871553). Low expression, if any, in normal colonic epithelial cells (at protein level). Levels tend to increase during colon cancer progression, from very low in benign hyperplastic polyps to very high in tubular and villous adenomas (PubMed:17699760).

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Cytoplasm, cytosol. In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Mammary Neoplasms
Malignant Neoplasm Of Breast
Cell Transformation, Neoplastic
Neoplasm Metastasis
Myotonic Dystrophy
Dystrophy
Radiation Injury
Embryonal Carcinoma
Tumor Progression
Colonic Neoplasms

Trinucleotide Repeat Expansion
Malignant Tumor Of Colon
Down Syndrome
Bone Neoplasms
Kidney Neoplasm
Influenza In Birds
Gastrointestinal Hemorrhage

Interacting Proteins

BYSL
DDX5
EXOSC3
GRB2
HDAC1

LNX1
NFAT5
RBM10
RBM15
SF1

Srek1
TP53
YAP1
Zc3hav1

Pathways

Translation
Cell Cycle
Rna Splicing
Cell Migration
Cell Proliferation
Localization
Pathogenesis
Cell Adhesion
Transport
Osteoblast Development
Brain Development
Virus-host Interaction
Regulation Of Gene Expression

Nuclear Export
Cell Cycle Arrest
Spermatogenesis
System Development
Cell Differentiation
Mrna Processing
Interphase

PTMs

Sumoylation
Phosphorylation

Cleavage
Acetylation

Research Areas

Translation Control
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDX17

References

PMID: 8871553 by Lamm G.M., et al. p72: a human nuclear DEAD box protein highly related to p68.

PMID: 26209609 by Yang J., et al. Systematic determination of human cyclin dependent kinase (CDK)-9 interactome identifies novel functions in RNA splicing mediated by the DEAD box (DDX)-5/17 RNA helicases.