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DDX1 Antibodies
AND DDX1 ELISA kits, DDX1 Proteins
Many biological assays use antibodies to detect DDX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDX1 antibodies...
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DDX1 Infographic by Boster Bio
All DDX1 Products
Product
Figures
Specificity
Applications
Price
Anti-DDX1 Antibody Picoband®
1 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03727-1
100 μg/vial
Cat # A03727-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03727
100 μg/vial
Cat # M03727
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M03727-1
100 μg/vial
Cat # M03727-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M03727-2
100 μg/vial
Cat # M03727-2
100 μg/vial
DDX1 Overview
Facts about ATP-dependent RNA helicase DDX1.
ATP-dependent RNA helicase DDX1 (DDX1)
Possesses 5' single-stranded RNA overhang nuclease action. Possesses ATPase activity on several different RNA, but not DNA polynucleotides.
May play a role in RNA clearance in DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to boost NF-kappa-B-mediated transcriptional activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | DDX1 |
| Uniprot: | Q92499 |
| Entrez: | 1653 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
ATP-dependent RNA helicase DDX1; DBP-RB; DBP-RBDEAD box polypeptide 1; DDX1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD box protein retinoblastoma; DEAD Box-1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1; DEAD/H-Box Helicase 1; EC 3.6.1; EC 3.6.1.10; EC 3.6.4.13; UKVH5d
Molecular Weight
Mass (kDA):
82.432 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p24.3 |
| Sequence: | 2; NC_000002.12 (15591868..15631101) |
Tissue Specificity
Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, cytosol. Mitochondrion. Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Enters into the nucleus in case of active tra
Diseases
- Neoplasms
- Neuroblastoma
- Retinoblastoma
- Malignant Neoplasms
- Hiv Infections
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Carcinoma
- Immunologic Deficiency Syndromes
- Mammary Neoplasms
- Brain Neoplasms
- Fracture Of First Cervical Vertebra
Pathways
- Translation
- Localization
- Transport
- Metaphase
- Pathogenesis
- Cell Cycle
- Nuclear Export
- Spermatogenesis
- Viral Transcription
- Interphase
- Rna Splicing
- Dna Replication
- Dna Amplification
PTMs
- Cleavage
Research Areas
- Cancer
- Neuroscience
- Transcription Factors and Regulators
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDX1
bosterbio.com/bosterbio-gene-info-cards/DDX1
References
PMID: 7689221 by Godbout R., et al. Amplification of a DEAD box protein gene in retinoblastoma cell lines.
PMID: 11598190 by Bleoo S., et al. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA.