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DDR1 Antibodies
AND DDR1 ELISA kits, DDR1 Proteins
Many biological assays use antibodies to detect DDR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDR1 antibodies...
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DDR1 Infographic by Boster Bio
All DDR1 Products
Product
Figures
Specificity
Applications
Price
Anti-Phospho-DDR1 (Y513) Antibody
1 Citations 15 Q&As
Human, Mouse, Rat
ELISA, IHC, WB
$399
Cat # P00905
100μl
Cat # P00905
100μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1167
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1167
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00905
100 μg/vial
Cat # A00905
100 μg/vial
DDR1 Overview
Facts about Epithelial discoidin domain-containing receptor 1.
Epithelial discoidin domain-containing receptor 1 (DDR1)
Tyrosine kinase that acts as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell regeneration. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.
Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal ear morphology and normal hearing (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | DDR1 |
| Uniprot: | Q08345 |
| Entrez: | 780 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CAK; CD167 antigen-like family member A; CD167a antigen; CD167a; DDR; DDR1; discoidin domain receptor family, member 1; discoidin domain receptor tyrosine kinase 1; Discoidin receptor tyrosine kinase; EC 2.7.10; EC 2.7.10.1; EDDR1; ENTRK4; Epithelial discoidin domain receptor 1; HGK2; MCK10; MCK-10; NTRK4; Protein-tyrosine kinase 3A; PTK3A protein tyrosine kinase 3A; PTK3A; receptor, type 4; RTK6; TRK E; TrkE
Molecular Weight
Mass (kDA):
101.128 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.33 |
| Sequence: | 6; NC_000006.12 (30880958..30900156) |
Tissue Specificity
Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Carcinoma
- Fibrosis
- Mammary Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Atherosclerosis
- Inflammation
- Leukemia
Interacting Proteins
- NCK2
- PTPN11
Pathways
- Cell Adhesion
- Cell Migration
- Cell Cycle
- Pathogenesis
- Localization
- Cell Proliferation
- Cell Growth
- Cell Differentiation
- Transport
- Chemotaxis
- G1 Phase
- Mammary Gland Development
- Myelination
PTMs
- Phosphorylation
- Cleavage
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDR1
bosterbio.com/bosterbio-gene-info-cards/DDR1
References
PMID: 8226977 by di Marco E., et al. Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.
PMID: 8390675 by Johnson J.D., et al. A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.
1 Publications of Boster DDR1 Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41598-018-23240-6, Complement C1q stimulates the progression of hepatocellular tumor through the ac...
*More publications can be found for each product on its corresponding product page