Dcstamp Antibodies

AND Dcstamp ELISA kits, Dcstamp Proteins

Many biological assays use antibodies to detect Dcstamp, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dcstamp in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dcstamp antibodies...

We validate the specificity of these antibodies to Dcstamp by testing them on tissues known to express Dcstamp positively and negatively. Browse below to find the Dcstamp antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Dcstamp Infographic by Boster Bio

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Dcstamp Overview

Facts about Dendritic cell-specific transmembrane protein.

Dendritic cell-specific transmembrane protein (Dcstamp)

Probable cell surface receptor which plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs).

Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors.

Gene Information

Mouse
Gene Name:	Dcstamp
Uniprot:	Q7TNJ0
Entrez:	75766

Family

Belongs to:

No superfamily

Alternative Names

DCSTAMP; DC-STAMP; dendritic cell-specific transmembrane protein; FIND; IL-4-induced Protein; TM7SF4; transmembrane 7 superfamily member 4

Molecular Weight

Mass (kDA):
53.876 kDA

Genomic Context


Mouse

Location:	15\|15 B3.1
Sequence:	15;

Tissue Specificity

Expressed in macrophages and bone marrow dendritic cells (BM-DC). Weakly expressed in the spleen and lymph node. Highly expressed in multi-nuclear osteoclasts compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). Isoform 1 and isoform 2 are expressed in osteoclasts.

Diseases

Malignant Neoplasms
Periodontitis
Osteitis Deformans
Tumor Progression
Carcinoma, Papillary
Gingivitis
Periodontitis, Juvenile
Carcinogenesis
Osteosarcoma
Chronic Periodontitis
Neoplasms
Sarcoidosis
Papillary Thyroid Carcinoma

Lymphoma
Osteoporosis
Bone Diseases
Infective Disorder
Granuloma
Periodontal Diseases
Thyroid Neoplasm

Pathways

Osteoclast Differentiation
Macrophage Fusion
Pathogenesis
Bone Resorption
Transport
Chemokine Production
Fertilization
Proteolysis
Immune Response

Localization
Lymphocyte Proliferation
Secretion

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dcstamp

References

PMID: 15452179 by Kukita T., et al. RANKL-induced DC-STAMP is essential for osteoclastogenesis.

PMID: 15601667 by Eleveld-Trancikova D., et al. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum.