Decorin Antibodies

Decorin (DCN)

May affect the speed of fibrils formation. .

Gene Information

Human
Gene Name:	DCN
Uniprot:	P07585
Entrez:	1634

Family

Belongs to:
small leucine-rich proteoglycan (SLRP) family

Alternative Names

Bone proteoglycan II; CSCD; DCN; decorin proteoglycan; Decorin; dermatan sulphate proteoglycans II; DSPG2; PG40; PGII; PG-II; PGS2; PG-S2; proteoglycan core protein; SLRR1B; SLRR1BPGS2; small leucine-rich protein 1B

Molecular Weight

Mass (kDA):
39.747 kDA

Genomic Context

Human
Location:	12q21.33
Sequence:	12; NC_000012.12 (91140484..91182817, complement)

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

• Neoplasms
• Malignant Neoplasms
• Fibrosis
• Tissue Adhesions
• Carcinoma
• Inflammation
• Kidney Diseases
• Cicatrix
• Tumor Angiogenesis
• Nervousness
• Hypertrophy
• Malignant Paraganglionic Neoplasm

• Nerve Degeneration
• Corneal Diseases
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Cell Invasion
• Depressive Disorder
• Decerebrate State

Interacting Proteins

• FAM20B
• FN1

Pathways

• Localization
• Cell Proliferation
• Pathogenesis
• Regeneration
• Cell Growth
• Transport
• Angiogenesis
• Secretion
• Cell Adhesion
• Aging
• Wound Healing
• Cell Migration
• Innervation

• Synaptic Transmission
• Endocytosis
• Sulfation
• Cell Cycle
• Reverse Transcription
• Glycosylation
• Translation

PTMs

• Phosphorylation
• Cleavage
• Glycosylation
• Sulphation
• Methylation
• Biotinylation
• Ubiquitination

• Deglycosylation
• Demethylation
• Dephosphorylation
• Reduction
• Amination
• Acetylation
• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCN

Boster Bio - Best Uses Of The DCN Marker

This guide will guide you through the use of Boster Bio's Anti-Decorin/DCN Marker. This guide will help you optimize your experiments and troubleshoot any issues that you may face. There are answers to a variety of questions, as well as a guide to optimize your Boster Bio experiments can improve your results and get the most of your Boster Bio system. Every researcher will face challenges. Every experiment is not perfect. Although proper controls can remove many mistakes but there are bound to be some issues with your experiment. Troubleshooting guides can guide you in the right direction.

Boster Bio's Anti-Decorin/DCN Marker

Anti-Decorin/DCN Markers have been used for decades to detect tumors, and Boster Bio's product PA1314, a human antigen is a prime example. This product reacts with Human, Mouse, and Rat decorin. It can be stored at -20 ° Celsius for six months. It is made up of 5 mg BSA, 0.05 mg of Thimerosal, and 0.04 percent NaN3.

The decorin protein is a leucine rich proteoglycan, which is found in connective tissue. It connects type 1 collagen fibrils and plays an important function in the assembly of matrix. It suppresses the growth of different types of cancer cells and has anti-tumorigenic properties in murine tumor models. Decorin is a gene with multiple variants of alternative spliced transcripts and mutations in the decorin gene have been linked with congenital stromal corneal dystrophy.

DCN interacts with TLR2/4 macrophages with high affinity. This causes transient autophosphorylation aswell as the internalization of the tumor suppressor PDCD4. DCN also reduces downstream IL-10 production which is a cytokine controlled by pro-inflammatory reactions within macrophages. Furthermore, DCN converts the immune response into a pro-inflammatory state, sending monocytes to the area of injury, and triggering the production of CCL2.

Applications

The DCN Marker has several applications. Its use in the study of cerebellar stellate/basket cell stellate is described. The spiny cartwheel analogy to DCN is also considered, as is the Golgi analogue. The electon microscopy technique is utilized to assess its utility for cerebellar stellate/basket cell studies. Different markers are available to investigate DCN expression.

Optimization

Immunohistochemistry can be used to detect antigens within cells. This method exploits the principle of antibodies that bind to antigens and detect their presence. The method is extremely sensitive and has the potential to detect a broad range of biological samples. Boster Bio optimization using the DCN marker has been designed to minimize the risks associated with immunohistochemistry. Please refer to the Immunohistochemistry Manual for more details.

Troubleshooting

You might be a communications expert seeking out ways to troubleshoot DCN Marker. The game played on the phone involves whispering messages. Human translation may cause issues and lead to communication gaps. Sharing information will reduce misinterpretation risk and help speed troubleshooting. However, not all information can easily be shared, including customer privacy concerns. Here are some tips to help you troubleshoot a telecommunications issue where your provider doesn't have all the data you require.