Deoxycytidine kinase Antibodies

Deoxycytidine kinase (DCK)

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate.

It is also a vital enzyme for the phosphorylation of numerous nucleoside analogs widely used as antiviral and chemotherapeutic agents. .

Gene Information

Human
Gene Name:	DCK
Uniprot:	P27707
Entrez:	1633

Family

Belongs to:
DCK/DGK family

Alternative Names

dCK; deoxycytidine kinase; EC 2.7.1; EC 2.7.1.74; MGC117410; MGC138632

Molecular Weight

Mass (kDA):
30.519 kDA

Genomic Context

Human
Location:	4q13.3
Sequence:	4; NC_000004.12 (70993649..71030914)

Subcellular Localizations

Nucleus.

Diseases

• Leukemia
• Malignant Neoplasms
• Neoplasms
• Myeloid Leukemia
• Leukemia, Myelocytic, Acute
• Hiv Infections
• Congenital Dyserythropoietic Anemia
• Carcinoma
• Adenocarcinoma
• Lung Neoplasms
• Acquired Immunodeficiency Syndrome
• Immunologic Deficiency Syndromes
• Mammary Neoplasms

• Malignant Neoplasm Of Pancreas
• Malignant Squamous Cell Neoplasm
• Stomach Neoplasms
• Leukemia L1210
• Lymphoma
• Hematologic Neoplasms
• Leukemia, Experimental

Pathways

• Transport
• Methylation
• Dna Methylation
• Drug Resistance
• Aging
• Proteolysis
• Regulation Of Secretion
• Cytokinetic Process
• Cytokinesis
• Flight
• Sensitization
• Translation
• Drug Transport

• Spindle Assembly
• T Cell Homeostatic Proliferation
• Metaphase
• Nucleoside Salvage
• Abscission
• Dna Replication
• Cell Death

PTMs

• Phosphorylation
• Methylation

• Cleavage
• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCK

Best Uses Of The DCK Marker From Boster Bio

This article will explain the benefits and applications of the DCK Marker. You will also learn the best place to purchase it from Boster Bio. This article was written and edited by an Boster Bio scientist. Below are the most effective uses for this product. Read on for more details. Once you've bought your DCK Marker you can start using it in your research. I hope you'll appreciate it!

Research applications of the DCK Marker

DCK is an epitope of an enzyme that is found in a variety of immune cells including B cells and T cells with CD8+. It may also be involved in the process of infiltration by immune cells. Numerous recent studies suggest that DCK can play an important role in the progression of liver cancer.

The DCK Marker has numerous applications in research, such as predicting the prognosis of patients suffering from liver cancer. The protein is necessary for normal lymphopoiesis and its expression is a determinant of the status of IgG gene rearrangements. It assists in identifying subpopulations and precursors to B cells. Hardy fractions consist of B220+IgM+ cells and B cells that express other genes, like A-D cells. The high DCK levels in patients with liver cancer indicate a poor prognosis.

dCK may play a role not only in cell survival but also in DNA repair and synthesis membrane phospholipids. However, the mechanisms underlying these roles are unknown. dCK for instance, is found in bone marrow and the thymus where it is expressed at its highest levels. Thymus cellularity in mice suffering from deficiency in dCK is reduced 90-fold in mice that are dCK knockouts.

In a recent study the intratumoral DCK expression was associated with RFS among patients with unresectable BTC. A correlation was also observed between DCK expression in patients with GB-cancer. These findings are in support of the development of new treatment strategies that incorporate predictive biomarkers. These insights could lead to personalized treatment plans for patients suffering from particular patterns of recurrence. However, this research is not without its limitations. Its application in cancer research can aid in early diagnosis as well as monitoring of patient responses to chemotherapy.