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- Table of Contents
Facts about Deleted in azoospermia protein 1.
Promotes germ-cell development to meiosis and formation of haploid germ cells. .
Human | |
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Gene Name: | DAZ1 |
Uniprot: | Q9NQZ3 |
Entrez: | 1617 |
Belongs to: |
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RRM DAZ family |
deleted in azoospermia 1; deleted in azoospermia; FLJ17175; SPGYDAZdeleted in azoospermia protein 1
Mass (kDA):
82.764 kDA
Human | |
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Location: | Yq11.223 |
Sequence: | Y; NC_000024.10 (23129355..23199117, complement) |
Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level).
Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
PMID: 10936047 by Saxena R., et al. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.
PMID: 10857750 by Tsui S., et al. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1.