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DAXX Antibodies
AND DAXX ELISA kits, DAXX Proteins
Many biological assays use antibodies to detect DAXX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DAXX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DAXX antibodies...
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DAXX Infographic by Boster Bio
All DAXX Products
Product
Figures
Specificity
Applications
Price
Anti-Daxx Antibody Picoband®
1 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9550
100 μg/vial
Cat # PB9550
100 μg/vial
Human
ELISA
$480
Cat # EKC1166
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1166
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2026
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2026
1 kit, containing two 96-well plates and all necessary reagents
DAXX Overview
Facts about Death domain-associated protein 6.
Death domain-associated protein 6 (DAXX)
Transcription corepressor proven to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription.
Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Appears to regulate transcription in PML/POD/ND10 atomic bodies together with PML and may affect TNFRSF6-dependent apoptosis thereby.
Gene Information
| Human | |
|---|---|
| Gene Name: | DAXX |
| Uniprot: | Q9UER7 |
| Entrez: | 1616 |
Family
| Belongs to: |
|---|
| DAXX family |
Alternative Names
BING2; CENP-C binding protein; DAP6; DAP6MGC126245; Daxx; death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126246
Molecular Weight
Mass (kDA):
81.373 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.32 |
| Sequence: | 6; NC_000006.12 (33318558..33323016, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome, centromere. Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stre
Diseases
- Leukemia
- Acute Promyelocytic Leukemia
- Neoplasms
- Malignant Neoplasms
- Cytomegalovirus Infections
- Virus Diseases
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Physiological Stress
- Cell Transformation, Neoplastic
- Prostatic Neoplasms
- Autoimmune Reaction
Interacting Proteins
- AIRE
- AR
- ATRX
- CARD9
- CDCA7L
- CDKN2A
- CREBBP
- FAM9B
- FAS
- Fas
Pathways
- Localization
- Cell Death
- Cell Cycle
- Pathogenesis
- Cell Proliferation
- Chromatin Remodeling
- Rna Interference
- Viral Replication
- Senescence
- Cell Growth
- Immune Response
- Mitosis
- Programmed Cell Death
PTMs
- Phosphorylation
- Sumoylation
- Acetylation
- Ubiquitination
- Methylation
Research Areas
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DAXX
bosterbio.com/bosterbio-gene-info-cards/DAXX
References
PMID: 9215629 by Yang X., et al. Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
PMID: 9407001 by Kiriakidou M., et al. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.