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- Table of Contents
Facts about Dystroglycan.
Human | |
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Gene Name: | DAG1 |
Uniprot: | Q14118 |
Entrez: | 1605 |
Belongs to: |
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No superfamily |
A3a; AGRNR; DAG156DAG; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystroglycan; Dystrophin-associated glycoprotein 1
Mass (kDA):
97.441 kDA
Human | |
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Location: | 3p21.31 |
Sequence: | 3; NC_000003.12 (49468703..49535618) |
Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts.
[Alpha-dystroglycan]: Secreted, extracellular space.; [Beta-dystroglycan]: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to
This article will outline some of the best uses and benefits of the DAG1 marker gene. This marker can be used to determine the toxicity of antibiotics on a variety of bacteria, including HIV-1. Research in vitro also uses the DAG1 gene. The DAG1 genome is expressed in a wide range of organisms, such as humans and other animals.
In vitro DAG1 immunohistochemistry is an excellent tool for the analysis of DAG1 expression levels in human tissues. Boster Bio sells antibodies to DAG1 and other sources. Boster Bio's antibody towards DAG1 reacts to human, mouse, and rats samples. This makes it an excellent choice for research in that field.
PMID: 8268918 by Ibraghimov-Beskrovnaya O., et al. Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization.
PMID: 7592992 by Jung D., et al. Identification and characterization of the dystrophin anchoring site on beta-dystroglycan.