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Dystroglycan Antibodies
AND DAG1 ELISA kits, Dystroglycan Proteins
Many biological assays use antibodies to detect Dystroglycan, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dystroglycan in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dystroglycan antibodies...
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DAG1 Infographic by Boster Bio
All DAG1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1614
96 wells/kit, with removable strips.
Cat # EK1614
96 wells/kit, with removable strips.
DAG1 Overview
Facts about Dystroglycan.
Dystroglycan (DAG1)
The dystroglycan complex is involved in a range of procedures including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DAG1 |
| Uniprot: | Q14118 |
| Entrez: | 1605 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
A3a; AGRNR; DAG156DAG; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystroglycan; Dystrophin-associated glycoprotein 1
Molecular Weight
Mass (kDA):
97.441 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (49468703..49535618) |
Tissue Specificity
Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts.
Subcellular Localizations
[Alpha-dystroglycan]: Secreted, extracellular space.; [Beta-dystroglycan]: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to
Diseases
- Muscular Dystrophy
- Dystrophy
- Congenital Muscular Dystrophy (disorder)
- Muscular Dystrophy, Duchenne
- Muscular Dystrophies, Limb-girdle
- Tissue Adhesions
- Myopathy
- Walker-warburg Congenital Muscular Dystrophy
- Nervousness
- Sarcoglycanopathies
- Muscle Eye Brain Disease
- Coronary Microvascular Disease
- Cardiomyopathies
Interacting Proteins
- NCK1
Pathways
- Glycosylation
- Pathogenesis
- Localization
- Cell Adhesion
- Regeneration
- Germination
- Basement Membrane Assembly
- Membrane Assembly
- Protein Glycosylation
- Seed Germination
- Cell Migration
- Cell Differentiation
- Muscle Hypertrophy
PTMs
- Glycosylation
- Cleavage
- Phosphorylation
Research Areas
- Breast Cancer
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DAG1
bosterbio.com/bosterbio-gene-info-cards/DAG1
References
PMID: 8268918 by Ibraghimov-Beskrovnaya O., et al. Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization.
PMID: 7592992 by Jung D., et al. Identification and characterization of the dystrophin anchoring site on beta-dystroglycan.