DAD1 Antibodies

AND DAD1 ELISA kits, DAD1 Proteins

Many biological assays use antibodies to detect DAD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DAD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DAD1 antibodies...

We validate the specificity of these antibodies to DAD1 by testing them on tissues known to express DAD1 positively and negatively. Browse below to find the DAD1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DAD1 Infographic by Boster Bio

All DAD1 Products

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Specificity

Applications

Price

Anti-DAD1 Antibody

Human, Mouse

ELISA, IF, ICC, WB

$449
Cat # A06054
0.1 mg

Anti-DAD1 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A06054-1
100ul

DAD1 Overview

Facts about Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1.

DAD1 3D structure. Source: alphafold

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a specified glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B- containing OST complexes.

Gene Information

Human
Gene Name:	DAD1
Uniprot:	P61803
Entrez:	1603

Family

Belongs to:

DAD/OST2 family

Alternative Names

DAD-1; defender against cell death 1EC 2.4.1.119; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase 2 homolog; OST2

Molecular Weight

Mass (kDA):
12.497 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (22564907..22589224, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Prostatic Neoplasms
Malignant Neoplasm Of Prostate
Liver Neoplasms
Cell Transformation, Neoplastic
Lymphoma
Plant Diseases
Adenocarcinoma
Liver Carcinoma
Sterility
Inflammation

Infective Disorder
Cell Invasion
Congenital Disorders
Fracture Of First Cervical Vertebra
Malignant Carcinoid Syndrome
Embryonal Carcinoma
Malignant Neoplasm Of Breast

Pathways

Cell Death
Glycosylation
Programmed Cell Death
Cell Cycle
Dehiscence
Anther Dehiscence
Cell Proliferation
Pathogenesis
Anaphase
Localization
Pollen Maturation
Germination
Transport

Chromosome Segregation
Translation
Senescence
Cell Growth
Rna Interference
Dna Repair
Organ Development

PTMs

Glycosylation

Cleavage

Phosphorylation

Research Areas

Apoptosis
Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DAD1

References

PMID: 8413235 by Nakashima T., et al. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells.

PMID: 22467853 by Roboti P., et al. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.