Dapper homolog 1 Antibodies

AND DACT1 ELISA kits, Dapper homolog 1 Proteins

Many biological assays use antibodies to detect Dapper homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dapper homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dapper homolog 1 antibodies...

We validate the specificity of these antibodies to Dapper homolog 1 by testing them on tissues known to express DACT1 positively and negatively. Browse below to find the DACT1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DACT1 Infographic by Boster Bio

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Anti-Dapper homolog 1 DACT1 Antibody

1 Q&As

Human

$341
Cat # A04683
100 µg

Anti-DACT1 Mouse Monoclonal Antibody [Clone ID: OTI13H4]

Human

$523
Cat # M04683
100 µl

DACT1 Overview

Facts about Dapper homolog 1.

DACT1 3D structure. Source: alphafold

Dapper homolog 1 (DACT1)

Involved in regulation of intracellular signaling pathways during evolution. Specifically believed to play a part in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity.

Gene Information

Human
Gene Name:	DACT1
Uniprot:	Q9NYF0
Entrez:	51339

Family

Belongs to:

dapper family

Alternative Names

DAPPER; dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis); DAPPER1dapper homolog 1, antagonist of beta-catenin (xenopus); DPR1dapper homolog 1, antagonist of beta-catenin; FRODOdapper homolog 1; HDPR1; Hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3; HNG3; THYEX3

Molecular Weight

Mass (kDA):
90.174 kDA

Genomic Context


Human

Location:	14q23.1
Sequence:	14; NC_000014.9 (58634061..58648321)

Subcellular Localizations

Cytoplasm. Nucleus. Cell junction, synapse. Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

Diseases

Malignant Neoplasms
Neoplasms
Congenital Abnormality
Neoplasm Metastasis
Carcinoma
Leukemia
Neoplasm Invasiveness
Colonic Neoplasms
Carcinogenesis
Cell Transformation, Neoplastic
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Tumor Of Colon
Cytoplasmic Accumulation

Cell Invasion
Acute Lymphocytic Leukemia
Malignant Neoplasm Of Stomach
Cholangiocarcinoma
Stomach Neoplasms
Sclerosis
Disease Of Adrenal Medulla

Interacting Proteins

CTNNB1
DVL2
GSK3B
YWHAB

Pathways

Methylation
Dna Methylation
Localization
Demethylation
Neural Tube Closure
Cell Proliferation
Tube Closure
Segmentation
Rna Interference
Cell Adhesion
Gene Silencing
Aging
Somitogenesis

Nuclear Export
Embryo Development
Regeneration
Reverse Transcription
Tissue Regeneration
Cellular Localization
Cell Cycle

PTMs

Methylation

Phosphorylation

Demethylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DACT1

References

PMID: 11970895 by Cheyette B.N.R., et al. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.

PMID: 15580286 by Yau T.O., et al. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing.