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- Table of Contents
Facts about RNA polymerase-associated protein CTR9 homolog.
PAF1C is necessary for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it boosts leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
Human | |
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Gene Name: | CTR9 |
Uniprot: | Q6PD62 |
Entrez: | 9646 |
Belongs to: |
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No superfamily |
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); KIAA0155SH2 domain-binding protein 1; p150TSP; RNA polymerase-associated protein CTR9 homolog; SH2 domain binding protein 1 (tetratricopeptide repeat containing); SH2BP1p150; TPR-containing, SH2-binding phosphoprotein; TSBP
Mass (kDA):
133.502 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (10751246..10779746) |
Widely expressed.
Nucleus speckle.
PMID: 16024656 by Zhu B., et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis.
PMID: 16307923 by Zhu B., et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.