COPS6 Antibodies

AND COPS6 ELISA kits, COPS6 Proteins

Many biological assays use antibodies to detect COPS6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COPS6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COPS6 antibodies...

We validate the specificity of these antibodies to COPS6 by testing them on tissues known to express COPS6 positively and negatively. Browse below to find the COPS6 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COPS6 Infographic by Boster Bio

All COPS6 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-COP9 Signalosome Csn6 Subunit COPS6 Antibody

4 Q&As

Human

$299
Cat # A08543
25μl/vial

Anti-COPS6 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A08543-1
100ul

COPS6 (NM_006833) Human Recombinant Protein

$813
Cat # PROTQ7L5N1
20 µg

Anti-COPS6 Mouse Monoclonal Antibody [Clone ID: OTI4E7]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M08543
100 µl

COPS6 (NM_006833) Human Over-expression Lysate

Human

$628
Cat # LS010980
100 µg

COPS6 Overview

Facts about COP9 signalosome complex subunit 6.

COPS6 3D structure. Source: alphafold

COP9 signalosome complex subunit 6 (COPS6)

Part of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes like SCF, CSA or DDB2.

The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN protects and promotes degradation from the Ubl system, respectively.

Gene Information

Human
Gene Name:	COPS6
Uniprot:	Q7L5N1
Entrez:	10980

Family

Belongs to:

peptidase M67A family

Alternative Names

BMP2B; BMP2B1; BMP4; COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); COP9 signalosome complex subunit 6; CSN6COP9 subunit 6 (MOV34 homolog, 34 kD); H_NH0506M12.12; HVIP; JAB1-containing signalosome subunit 6; MOFC11; MOV34 homolog; MOV34 homolog, 34 kD; MOV34-34KD; SGN6; Signalosome subunit 6; Vpr-interacting protein

Molecular Weight

Mass (kDA):
36.163 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (100088969..100092187)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Cytoplasm.; Cytoplasm, perinuclear region. (Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.

Diseases

Immunologic Deficiency Syndromes
Hiv Infections
Myeloproliferative Disease
Stomach Neoplasms
Adenocarcinoma
Malignant Neoplasms
Neoplasms

Decreased Immunologic Activity [pe]
Esophageal Neoplasms

Interacting Proteins

BTBD2
COP1
COPS3
COPS4
COPS5

MAPK1
SFN

Pathways

Cell Cycle
Cell Cycle Arrest
Translation
Convergent Extension
G2 Phase
G1 Phase
Proteolysis
Localization
Dna Replication
Cell Death

Dna Damage Checkpoint
S Phase
Segmentation
Pathogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPS6

References

PMID: 9341143 by Asano K., et al. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.

PMID: 9535219 by Seeger M., et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.