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Cnot7 Antibodies
AND Cnot7 ELISA kits, Cnot7 Proteins
Many biological assays use antibodies to detect Cnot7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cnot7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cnot7 antibodies...
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Cnot7 Overview
Facts about CCR4-NOT transcription complex subunit 7.
CCR4-NOT transcription complex subunit 7 (Cnot7)
Its function appears to be somewhat redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to several cellular processes including majority mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
Throughout miRNA-mediated repression the complex appears also to act as translational repressor through translational initiation. Additional complex functions might be a consequence of its influence on mRNA expression.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cnot7 |
| Uniprot: | Q60809 |
| Entrez: | 18983 |
Family
| Belongs to: |
|---|
| CAF1 family |
Alternative Names
BTG1 binding factor 1; BTG1-binding factor 1; CAF-1; CAF1carbon catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; CCR4-NOT transcription complex, subunit 7; hCAF-1
Molecular Weight
Mass (kDA):
32.718 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 8|8 A4 |
| Sequence: | 8; |
Diseases
- Infertility
- Malignant Neoplasms
- Neoplasms
- Male Infertility
- Oligospermia
- Carcinoma, Krebs 2
- Endometrial Polyp
- Spermatogenesis Abnormal
- Overlap Connective Tissue Disease
- Carcinoma
- Leukemia, Myelocytic, Acute
- Osteosarcoma
- Injury To Liver
Pathways
- Cell Cycle
- Cell Proliferation
- Spermatogenesis
- Translation
- Regulation Of Gene Expression
- Rna Interference
- Cell Adhesion
- Heterochromatin Organization
- Fertilization
- Dna Demethylation
- Mrna Destabilization
- Hepatocyte Proliferation
- Cell Cycle Arrest
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cnot7
bosterbio.com/bosterbio-gene-info-cards/Cnot7
References
PMID: 7791755 by Draper M.P., et al. Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.
PMID: 9712883 by Rouault J.P., et al. Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.