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- Table of Contents
Facts about POU domain, class 2, transcription factor 2.
Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
Human | |
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Gene Name: | POU2F2 |
Uniprot: | P09086 |
Entrez: | 5452 |
Belongs to: |
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POU transcription factor family |
homeobox protein; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; OCT2Oct-2; Octamer-binding protein 2; Octamer-binding transcription factor 2; OTF-2; OTF2POU domain class 2, transcription factor 2; POU class 2 homeobox 2; POU domain, class 2, transcription factor 2
Mass (kDA):
51.209 kDA
Human | |
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Location: | 19q13.2 |
Sequence: | 19; NC_000019.10 (42086113..42197931, complement) |
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
Cytoplasm. Nucleus.
PMID: 3265124 by Clerc R.G., et al. The B-cell-specific Oct-2 protein contains POU box- and homeo box- type domains.
PMID: 2904654 by Scheidereit C., et al. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.