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- Table of Contents
, No Gclids
Clusterin Antibodies
AND CLU ELISA kits, Clusterin Proteins
Many biological assays use antibodies to detect Clusterin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Clusterin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Clusterin antibodies...
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CLU Infographic by Boster Bio
All CLU Products
Product
Figures
Specificity
Applications
Price
Anti-Apolipoprotein J/CLU Antibody Picoband®
2 Citations 6 Q&As
Human
ELISA, IHC, WB
$370
Cat # PB9575
100 μg/vial
Cat # PB9575
100 μg/vial
Human Clusterin ELISA Kit PicoKine®
8 Citations 6 Q&As
Human
ELISA
$499
Cat # EK0914
96 wells/kit, with removable strips.
Cat # EK0914
96 wells/kit, with removable strips.
Mouse Clusterin / Apolipoprotein J ELISA Kit PicoKine®
1 Citations 8 Q&As
Mouse
ELISA
$499
Cat # EK0923
96 wells/kit, with removable strips.
Cat # EK0923
96 wells/kit, with removable strips.
Rat Clusterin ELISA Kit PicoKine®
2 Citations 6 Q&As
Rat
ELISA
$499
Cat # EK1615
96 wells/kit, with removable strips.
Cat # EK1615
96 wells/kit, with removable strips.
Human
IP, IHC-P, IHC-F, ICC, WB
$518
Cat # M00590
100µg
Cat # M00590
100µg
Human
ELISA
$499
Cat # FEK0914
96 wells/kit, with removable strips.
Cat # FEK0914
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, WB, IHC-P-Leica
$299
Cat # A00590-2
80 µl
Cat # A00590-2
80 µl
CLU Overview
Facts about Clusterin.
Clusterin (CLU)
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Inhibits formation of amyloid fibrils from APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro).
Doesn't require ATP. Maintains partially unfolded proteins in a country suitable for subsequent refolding by other chaperones, for example HSPA8/HSC70.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLU |
| Uniprot: | P10909 |
| Entrez: | 1191 |
Family
| Belongs to: |
|---|
| clusterin family |
Alternative Names
40; 40, sulfated glycoprotein 2; Aging-associated gene 4 protein; aging-associated protein 4; APOJ; apo-J; Apolipoprotein J; CLI; CLIclusterin (complement lysis inhibitor, SP-40; CLU; Clusterin; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40; Ku70-binding protein 1; KUB1SGP2; MGC24903; NA1/NA2; SGP-2; SP-40; sulfated glycoprotein 2; Testosterone-repressed prostate message 2; testosterone-repressed prostate message 2, apolipoprotein J); TRPM-2; TRPM-2TRPM2
Molecular Weight
Mass (kDA):
52.495 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.1 |
| Sequence: | 8; NC_000008.11 (27596917..27614700, complement) |
Tissue Specificity
Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
Subcellular Localizations
[Isoform 1]: Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.; [Isoform 4]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; [Isoform 6]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted isoforms can retrotransl
Diseases
- Malignant Neoplasms
- Neoplasms
- Alzheimer's Disease
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Carcinoma
- Inflammation
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Kidney Diseases
Interacting Proteins
- ADCYAP1
- APP
- DISC1
- FOS
- MSRB1
- PDIA3
- PPARG
Pathways
- Cell Death
- Pathogenesis
- Localization
- Transport
- Secretion
- Cell Cycle
- Cell Proliferation
- Aging
- Programmed Cell Death
- Cell Growth
- Senescence
- Induction Of Apoptosis
- Complement Activation
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Methylation
- Oxidation
- Sulphation
- Reduction
Research Areas
- Apoptosis
- Cancer
- Cytokine Research
- Dendritic Cell Markers
- Hypoxia
- Immunology
- Innate Immunity
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLU
bosterbio.com/bosterbio-gene-info-cards/CLU
References
PMID: 2780565 by Jenne D.E., et al. Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.
PMID: 8181474 by Wong P., et al. Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.
13 Publications of Boster Clusterin Antibodies & ELISA Kits
- PubMed ID: 10.1111/cen.13360, Urine clusterin/apolipoprotein J is linked to tubular damage and renal outcomes...
- PubMed ID: 10.1080/17435390.2018.1513093, Activated iRhom2 drives prolonged PM2.5 exposure-triggered renal injury in Nrf2-...
- PubMed ID: 10.1080/09553002.2020.1739775, Identification of the differentially expressed protein biomarkers in rat blood p...
- PubMed ID: 10.1007/s13277-015-3875-3, Diagnostic and prognostic significance of secretory clusterin expression in pati...
- PubMed ID: 10.1002/2211-5463.12997, Cystatin C regulates the cytotoxicity of infection‐induced endothelial‐deriv...
- PubMed ID: , Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insul...
- PubMed ID: 33030263, Balczon R, Morrow KA, Leavesley S, Francis CM, Stevens TC, Agwaramgbo E, William...
- PubMed ID: 33356806, Chen QF,Zhang L,Su Q,Zhao Y,Kong B.Clinical importance of serum secreted cluster...
- PubMed ID: 32149567, Identification of the differentially expressed protein biomarkers in rat blood p...
- PubMed ID: 26264614 , Diagnostic and prognostic significance of secretory clusterin expression in pati...
- PubMed ID: 28881732, Oncogenic secretory clusterin in hepatocellular carcinoma: Expression at early s...
- PubMed ID: 28434209, Urine clusterin/apolipoprotein J is linked to tubular damage and renal outcomes ...
- PubMed ID: 29686328, Song J, Zhang Y, Zhang C, Du X, Guo Z, Kuang Y, Wang Y, Wu P, Zou K, Zou L, Lv J...
*More publications can be found for each product on its corresponding product page