Clusterin Antibodies

Clusterin (CLU)

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Inhibits formation of amyloid fibrils from APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro).

Doesn't require ATP. Maintains partially unfolded proteins in a country suitable for subsequent refolding by other chaperones, for example HSPA8/HSC70.

Gene Information

Human
Gene Name:	CLU
Uniprot:	P10909
Entrez:	1191

Family

Belongs to:
clusterin family

Alternative Names

40; 40, sulfated glycoprotein 2; Aging-associated gene 4 protein; aging-associated protein 4; APOJ; apo-J; Apolipoprotein J; CLI; CLIclusterin (complement lysis inhibitor, SP-40; CLU; Clusterin; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40; Ku70-binding protein 1; KUB1SGP2; MGC24903; NA1/NA2; SGP-2; SP-40; sulfated glycoprotein 2; Testosterone-repressed prostate message 2; testosterone-repressed prostate message 2, apolipoprotein J); TRPM-2; TRPM-2TRPM2

Molecular Weight

Mass (kDA):
52.495 kDA

Genomic Context

Human
Location:	8p21.1
Sequence:	8; NC_000008.11 (27596917..27614700, complement)

Tissue Specificity

Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.

Subcellular Localizations

[Isoform 1]: Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.; [Isoform 4]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; [Isoform 6]: Cytoplasm. Keeps cytoplasmic localization in stressed and unstressed cell.; Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted isoforms can retrotransl

Diseases

• Malignant Neoplasms
• Neoplasms
• Alzheimer's Disease
• Prostatic Neoplasms
• Malignant Neoplasm Of Prostate
• Carcinoma
• Inflammation
• Malignant Neoplasm Of Breast
• Cell Transformation, Neoplastic
• Mammary Neoplasms
• Neoplasm Metastasis
• Malignant Paraganglionic Neoplasm
• Kidney Diseases

• Atherosclerosis
• Nerve Degeneration
• Tumor Progression
• Adenocarcinoma
• Senile Plaques
• Plaque, Amyloid
• Dementia

Interacting Proteins

• ADCYAP1
• APP
• DISC1
• FOS
• MSRB1

• PDIA3
• PPARG

Pathways

• Cell Death
• Pathogenesis
• Localization
• Transport
• Secretion
• Cell Cycle
• Cell Proliferation
• Aging
• Programmed Cell Death
• Cell Growth
• Senescence
• Induction Of Apoptosis
• Complement Activation

• Dna Repair
• Cytolysis
• Lipid Transport
• Glycosylation
• Translation
• Regeneration
• Tissue Remodeling

PTMs

• Cleavage
• Phosphorylation
• Glycosylation
• Methylation
• Oxidation
• Sulphation
• Reduction

• Acetylation
• Demethylation
• Deglycosylation
• Phosphorothioation
• Ubiquitination
• Biotinylation
• Dephosphorylation

• Deacetylation

Research Areas

• Apoptosis
• Cancer
• Cytokine Research
• Dendritic Cell Markers
• Hypoxia

• Immunology
• Innate Immunity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLU

Boster Bio CLU Marker and Anti-IL2RA Antibodies - Best Uses of the CLU Marker

You have come to the right spot if you are looking for the best Boster bio: Anti-CLU marker anti-IL2RA or anti-Calbindin antibodies. Read on to learn more about these products and their greatest applications. Below are some examples of how they work. The CLU Marker has been found to be useful in many applications which include cell biology, immunology, cytology, immunology, and the field of virology.

Boster Bio Anti-CLU Marker

The Boster Bio Anti-CLU Marker monoclonal antibody reacts with human mouse, rat, or CLU. The antibody is produced by immunizing rabbits using the peptide which spans from the amino acids 71-99 in the N-terminal portion of the human CLU protein. The antibody was validated with known positive and negative samples. It is available as a reagent in the bi-component version and a single component version.

Boster Bio Anti-IL2RA Antibody

Boster Bio AntiIL2RA Antibodies can be used as monoclonal antibody to react with human IL-2Ralpha. They are flow validated and can bind to a specific protein or infectious protein. These antibodies include vascular endothelial growth factors (VEGF) and insulin-like growth factor(IGF) bone morphogenic proteins (BMP) and the basic fibroblast-growth factor (FGF) epidermal and epidermal growth hormones (EGF), neuregulin, and hepatocyte growth cytokine.

The CLU marker is the identifier of the engineered polypeptide the antigen will bind to. The antibody is comprised of light and heavy chain polypeptide segments, which are in a particular order. The sequence of human light chains is described by Kabat et al. (1991). SEQ ID NO. 3 is the constant area of the engineered antibodies.

Reconciling the antibodies is another method to determine affinity. To accomplish this, the engineered antibodies are compared against the donor antibody. The engineered antibodies are able to detect rare amino acids within the CDR or adjacent, as well as within three-amino acid regions (CLU). If the CLU marker does not exist the antibody can be modified by back mutation to restore its affinity.

The engineered antibodies contain the ribosomal binding spots, polyadenylation signal enhancer sequences and polyadenylation signs. Once they have bound to the antigen, the antibody will produce a therapeutic effect in the human body. This technology could alter the way that patients receive treatment. It is employed in many industries, including the pharmaceutical and biotech industries. While antibodies are frequently employed to treat multiple inflammatory and metabolic disorders, they can also prove useful for the prevention of autoimmune diseases.

Boster Bio Anti-Calbindin Antibody

Boster Bio Anti-Calbindin Antibodies bind to CLU proteins of rat mice, human and. This antibody is produced by immunizing rabbits with a peptide spanning the N-terminal portion of human CLU. Cross-reactivity is confirmed by positive and negative samples. Using this antibody to conduct your research will assist you in determining if your samples contain an cellular protein that is of interest.