CLIC2 Antibodies

AND CLIC2 ELISA kits, CLIC2 Proteins

Many biological assays use antibodies to detect CLIC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLIC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLIC2 antibodies...

We validate the specificity of these antibodies to CLIC2 by testing them on tissues known to express CLIC2 positively and negatively. Browse below to find the CLIC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLIC2 Infographic by Boster Bio

All CLIC2 Products

Product

Figures

Specificity

Applications

Price

CLIC2 (NM_001289) Human Recombinant Protein

$1249
Cat # PROTO15247
20 µg

CLIC2 (NM_001289) Human Over-expression Lysate

Human

$628
Cat # LS001193
100 µg

CLIC2 Overview

Facts about Chloride intracellular channel protein 2.

CLIC2 3D structure. Source: alphafold

Chloride intracellular channel protein 2 (CLIC2)

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH.

Membrane insertion seems to be redox-regulated and might occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.

Gene Information

Human
Gene Name:	CLIC2
Uniprot:	O15247
Entrez:	1193

Family

Belongs to:

chloride channel CLIC family

Alternative Names

chloride intracellular channel 2; chloride intracellular channel protein 2; XAP121CLIC2b

Molecular Weight

Mass (kDA):
28.356 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (155276211..155334614, complement)

Tissue Specificity

Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney.

Subcellular Localizations

Cytoplasm. Membrane; Single-pass membrane protein. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

Diseases

Dysplasia
Lupus Erythematosus, Systemic
Hereditary Diseases
Genetic Diseases, X-linked
Spondyloepiphyseal Dysplasia
Autoimmune Reaction
Late Spondyloepiphyseal Dysplasia
Monosomy
Liver Diseases
Malignant Neoplasm Of Breast
Communicable Diseases
Carcinoma

Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Malignant Neoplasms
Bacterial Infections
Arthritis, Juvenile Rheumatoid
Biliary Cirrhosis
Infective Disorder
Developmental Delay (disorder)

Pathways

Methylation
Transport
Cell Motility
Chloride Transport
Ion Transport

PTMs

Methylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLIC2

References

PMID: 9339381 by Heiss N.S., et al. Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.

PMID: 12681486 by Fan L., et al. Interaction of sedlin with chloride intracellular channel proteins.