CLK3 Antibodies

AND CLK3 ELISA kits, CLK3 Proteins

Many biological assays use antibodies to detect CLK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLK3 antibodies...

We validate the specificity of these antibodies to CLK3 by testing them on tissues known to express CLK3 positively and negatively. Browse below to find the CLK3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLK3 Infographic by Boster Bio

All CLK3 Products

Product

Figures

Specificity

Applications

Price

Anti-CLK3 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A08930
100ul

CLK3 (NM_003992) Human Over-expression Lysate

Human

$628
Cat # LS001198
100 µg

CLK3 Overview

Facts about Dual specificity protein kinase CLK3.

CLK3 3D structure. Source: alphafold

Dual specificity protein kinase CLK3 (CLK3)

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex.

May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3.

Gene Information

Human
Gene Name:	CLK3
Uniprot:	P49761
Entrez:	1198

Family

Belongs to:

protein kinase superfamily

Alternative Names

CDC-like kinase 3PHCLK3; clk3; dual specificity protein kinase CLK3; EC 2.7.12.1; FLJ22858; PHCLK3/152

Molecular Weight

Mass (kDA):
73.515 kDA

Genomic Context


Human

Location:	15q24.1
Sequence:	15; NC_000015.10 (74608372..74630201)

Tissue Specificity

Endothelial cells.

Subcellular Localizations

[Isoform 1]: Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.; [Isoform 2]: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.

Diseases

Malignant Neoplasms
Alzheimer's Disease
Infective Disorder
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Liver Carcinoma
Hepatitis
Neurodegenerative Disorders
Pulmonary Fibrosis
Down Syndrome
Hepatitis B
Malignant Neoplasm Of Liver
Carcinoma

Acute Erythroblastic Leukemia
Fibrosis
Prostatic Neoplasms
Neoplasms
Azoospermia
Inflammation
Myositis

Interacting Proteins

CLK2
HOXB6
HOXB7
OAS2
RBMX

RBMY1A1
RBMY1F
RSRP1
SDCBP
SRPK2

SUV39H1
TINF2
TRA2B
ZNF263

Pathways

Cell Cycle
Reverse Transcription
Protein Phosphorylation
Hyperphosphorylation
Catagen
Brain Development
Localization
Rna Splicing
Cell Death
Cell Differentiation
Anagen
Telogen

Cell Growth
Mrna Processing
Mrna Polyadenylation
Rna Interference
Oncogenesis
Secretion

PTMs

Phosphorylation

Dephosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLK3

References

PMID: 7990150 by Hanes J.J., et al. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PMID: 9637771 by Duncan P.I., et al. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.